Spleen in haematological malignancies

Spectrum of imaging findings

Sachin Saboo, K. M. Krajewski, K. N. O'Regan, A. Giardino, J. R. Brown, N. Ramaiya, J. P. Jagannathan

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Imaging morphology and metabolic activity of splenic lesions is of paramount importance in patients with haematological malignancies; it can alter tumour staging, treatment protocols and overall prognosis. CT, MRI and positron emission tomography (PET)/CT have been shown to be powerful tools for the non-invasive assessment of splenic involvement in various haematological malignancies. Since many haematological malignancies and non-neoplastic conditions can involve the spleen and imaging manifestations can overlap, imaging and clinical findings outside of the spleen should be looked for to narrow the differential diagnosis; confirmation can be obtained by pathological findings. Radiologists should be familiar with the cross-sectional imaging patterns of haematological malignancies involving the spleen as well as non-neoplastic splenic findings common in these patients to facilitate their care and follow-up. This pictorial review provides the common and uncommon imaging appearances and complications of various haematological malignancies involving the spleen on CT, MRI and PET/CT, and common pitfalls in diagnosis.

Original languageEnglish (US)
Pages (from-to)81-92
Number of pages12
JournalBritish Journal of Radiology
Volume85
Issue number1009
DOIs
StatePublished - Jan 2012

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Hematologic Neoplasms
Spleen
Positron-Emission Tomography
Aftercare
Neoplasm Staging
Clinical Protocols
Differential Diagnosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Saboo, S., Krajewski, K. M., O'Regan, K. N., Giardino, A., Brown, J. R., Ramaiya, N., & Jagannathan, J. P. (2012). Spleen in haematological malignancies: Spectrum of imaging findings. British Journal of Radiology, 85(1009), 81-92. https://doi.org/10.1259/bjr/31542964

Spleen in haematological malignancies : Spectrum of imaging findings. / Saboo, Sachin; Krajewski, K. M.; O'Regan, K. N.; Giardino, A.; Brown, J. R.; Ramaiya, N.; Jagannathan, J. P.

In: British Journal of Radiology, Vol. 85, No. 1009, 01.2012, p. 81-92.

Research output: Contribution to journalArticle

Saboo, S, Krajewski, KM, O'Regan, KN, Giardino, A, Brown, JR, Ramaiya, N & Jagannathan, JP 2012, 'Spleen in haematological malignancies: Spectrum of imaging findings', British Journal of Radiology, vol. 85, no. 1009, pp. 81-92. https://doi.org/10.1259/bjr/31542964
Saboo S, Krajewski KM, O'Regan KN, Giardino A, Brown JR, Ramaiya N et al. Spleen in haematological malignancies: Spectrum of imaging findings. British Journal of Radiology. 2012 Jan;85(1009):81-92. https://doi.org/10.1259/bjr/31542964
Saboo, Sachin ; Krajewski, K. M. ; O'Regan, K. N. ; Giardino, A. ; Brown, J. R. ; Ramaiya, N. ; Jagannathan, J. P. / Spleen in haematological malignancies : Spectrum of imaging findings. In: British Journal of Radiology. 2012 ; Vol. 85, No. 1009. pp. 81-92.
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