Spleen in haematological malignancies: Spectrum of imaging findings

Sachin Saboo, K. M. Krajewski, K. N. O'Regan, A. Giardino, J. R. Brown, N. Ramaiya, J. P. Jagannathan

Research output: Contribution to journalReview article

45 Scopus citations


Imaging morphology and metabolic activity of splenic lesions is of paramount importance in patients with haematological malignancies; it can alter tumour staging, treatment protocols and overall prognosis. CT, MRI and positron emission tomography (PET)/CT have been shown to be powerful tools for the non-invasive assessment of splenic involvement in various haematological malignancies. Since many haematological malignancies and non-neoplastic conditions can involve the spleen and imaging manifestations can overlap, imaging and clinical findings outside of the spleen should be looked for to narrow the differential diagnosis; confirmation can be obtained by pathological findings. Radiologists should be familiar with the cross-sectional imaging patterns of haematological malignancies involving the spleen as well as non-neoplastic splenic findings common in these patients to facilitate their care and follow-up. This pictorial review provides the common and uncommon imaging appearances and complications of various haematological malignancies involving the spleen on CT, MRI and PET/CT, and common pitfalls in diagnosis.

Original languageEnglish (US)
Pages (from-to)81-92
Number of pages12
JournalBritish Journal of Radiology
Issue number1009
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Saboo, S., Krajewski, K. M., O'Regan, K. N., Giardino, A., Brown, J. R., Ramaiya, N., & Jagannathan, J. P. (2012). Spleen in haematological malignancies: Spectrum of imaging findings. British Journal of Radiology, 85(1009), 81-92. https://doi.org/10.1259/bjr/31542964