Splenic rupture in hemophilia

D. W. Fort, J. C. Bernini, A. Johnson, C. J. Cochran, G. R. Buchanan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: Little information is available regarding splenic injury in patients with hemophilia. We describe here the management of splenic rupture in five of our patients with hemophilia and summarize the literature describing this complication. Patients and Methods: Two human immunodeficiency virus-seropositive patients were managed medically and did not require splenectomy. A third patient had a high titer inhibitor to both porcine and human factor VIII and required emergency splenectomy. Two boys had not been previously diagnosed with hemophilia until they underwent splenectomy after abdominal trauma. Results: All five patients survived. Conclusions: These cases demonstrate that nonsurgical management of splenic injury in patients with hemophilia can be performed safely and that splenectomy can be successfully performed despite a high titer of factor VIII inhibitor.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalAmerican Journal of Pediatric Hematology/Oncology
Volume16
Issue number3
StatePublished - 1994

Fingerprint

Splenic Rupture
Hemophilia A
Splenectomy
Wounds and Injuries
Factor VIII
Emergencies
Swine
HIV

Keywords

  • Hemophilia
  • Splenic rupture

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Cite this

Fort, D. W., Bernini, J. C., Johnson, A., Cochran, C. J., & Buchanan, G. R. (1994). Splenic rupture in hemophilia. American Journal of Pediatric Hematology/Oncology, 16(3), 255-259.

Splenic rupture in hemophilia. / Fort, D. W.; Bernini, J. C.; Johnson, A.; Cochran, C. J.; Buchanan, G. R.

In: American Journal of Pediatric Hematology/Oncology, Vol. 16, No. 3, 1994, p. 255-259.

Research output: Contribution to journalArticle

Fort, DW, Bernini, JC, Johnson, A, Cochran, CJ & Buchanan, GR 1994, 'Splenic rupture in hemophilia', American Journal of Pediatric Hematology/Oncology, vol. 16, no. 3, pp. 255-259.
Fort DW, Bernini JC, Johnson A, Cochran CJ, Buchanan GR. Splenic rupture in hemophilia. American Journal of Pediatric Hematology/Oncology. 1994;16(3):255-259.
Fort, D. W. ; Bernini, J. C. ; Johnson, A. ; Cochran, C. J. ; Buchanan, G. R. / Splenic rupture in hemophilia. In: American Journal of Pediatric Hematology/Oncology. 1994 ; Vol. 16, No. 3. pp. 255-259.
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