Sporadic lymphoplasmacytic cholecystitis: A clinicopathologic entity

Suntrea T G Hammer, Henry D. Appelman

Research output: Contribution to journalArticle

Abstract

Objectives: To describe a sporadic form of lymphoplasmacytic cholecystitis (LPC), a condition known to occur in patients with chronic biliary tract disease.

Methods: One year's worth of cholecystectomies was reviewed for sporadic cases of LPC. Histologic, radiologic, and clinical findings were reviewed and compared with noninflamed controls. Sporadic cases were also compared histologically with obstructive LPC cases.

Results: Sporadic LPC made up 7% of cholecystectomies, had a male predominance (54.2%), and more often presented with clinical signs of acute inflammation compared with controls. Radiologic findings identified gallstones in 71.4% of patients. The second most common finding was unexplained extrahepatic biliary dilation. There were no unique histologic findings to separate sporadic cases from those associated with pancreatobiliary disease.

Conclusions: While obstructive LPC is traditionally described as acalculous, chronic cholecystitis, we show this inflammatory pattern occurs both in the presence of gallstones and outside of previously described disease categories. In addition, LPC occurs in a unique patient demographic (older men), often presenting similarly to acute cholecystitis.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume142
Issue number2
DOIs
StatePublished - Aug 1 2014

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Cholecystitis
Cholecystectomy
Gallstones
Acalculous Cholecystitis
Biliary Tract Diseases
Acute Cholecystitis
Dilatation
Demography
Inflammation

Keywords

  • Chronic cholecystitis
  • Lymphoplasmacytic cholecystitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Sporadic lymphoplasmacytic cholecystitis : A clinicopathologic entity. / Hammer, Suntrea T G; Appelman, Henry D.

In: American Journal of Clinical Pathology, Vol. 142, No. 2, 01.08.2014, p. 209-212.

Research output: Contribution to journalArticle

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