Spotlight on atezolizumab and its potential in the treatment of advanced urothelial bladder cancer

Ahmet Murat Aydin, Solomon L. Woldu, Ryan C. Hutchinson, Martin Boegemann, Aditya Bagrodia, Yair Lotan, Vitaly Margulis, Laura Maria Krabbe

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Metastatic urothelial carcinoma of the bladder is an aggressive malignancy with poor prognosis, reflecting a lack of effective systemic therapies. The current standard of care includes multiagent platinum-based chemotherapy; however a majority of patients do not respond to treatment and most eventually succumb to disease. Recently, renewed interest in immunotherapy in the form of immune-checkpoint inhibition has gained widespread attention for a number of malignancies. Atezolizumab, an anti-PDL1 antibody, has been shown to be effective in a subset of patients previously treated with or unfit for platinum-based chemotherapy, and has shown durable responses with a good tolerability profile. We review the mechanism of action and clinical evidence of atezolizumab for metastatic urothelial bladder cancer, and discuss this drug within the context of ongoing developments in this dynamic field of immunooncology.

Original languageEnglish (US)
Pages (from-to)1487-1502
Number of pages16
JournalOncoTargets and Therapy
Volume10
DOIs
Publication statusPublished - Mar 9 2017

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Keywords

  • Atezolizumab
  • Bladder cancer
  • Immunotherapy
  • Metastatic
  • MPDL3280A
  • PDL1

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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