Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus

Xiao Nan Dong, Ying Hua Chen

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Our previous study proved that the N-terminal (aa693-711) of glycoprotein E2 contained sequential neutralizing epitopes. In this study, four candidate epitope-vaccines (EVs) were separately prepared and evaluated. Among them, epitope-vaccine EV-BC1a (BC1a: aa693-699) induced high level of epitope-specific neutralizing antibodies and exhibited similar protective capability with that induced by Chinese vaccine strain (C-strain). These results confirmed CKEDYRY (aa693-699) as a principal sequential neutralizing epitope on E2 N-terminal. Moreover, these findings also indicate that epitope-vaccine is a potent candidate strategy for marker vaccine against classical swine fever virus (CSFV).

Original languageEnglish (US)
Pages (from-to)4029-4034
Number of pages6
JournalVaccine
Volume24
Issue number19
DOIs
StatePublished - May 8 2006

Keywords

  • Classical swine fever virus (CSFV)
  • Epitope-vaccine
  • Marker vaccine
  • Sequential neutralizing epitope

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Fingerprint Dive into the research topics of 'Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus'. Together they form a unique fingerprint.

  • Cite this