Squamous cell carcinoma of the nail bed: Is finger predominance another clue to etiology? A report of 5 cases

Edward J. Zabawski, Ronald V. Washak, Jack B. Cohen, Clay J. Cockerell, Stuart M. Brown

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Although squamous cell carcinoma (SCC) is commonly found on sun-exposed skin, the occurrence of this malignancy in the nail bed is rare. We report 5 cases of SCC of the nail bed and suggest that the disproportionate number of neoplasms of this type on the second, third, and fourth fingers, combined with the known relationship of SCC and human papillomavirus (HPV), is evidence that most SCC of the nail bed result from contact with HPV. Moreover, we suggest that patients who present with new, verrucous lesions of the nail bed and have a history of cervical dysplasia, cervical carcinoma, or condyloma acuminata undergo diagnostic biopsy as opposed to traditional destructive therapy for a lesion presumed benign.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalCutis
Volume67
Issue number1
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Dermatology

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    Zabawski, E. J., Washak, R. V., Cohen, J. B., Cockerell, C. J., & Brown, S. M. (2001). Squamous cell carcinoma of the nail bed: Is finger predominance another clue to etiology? A report of 5 cases. Cutis, 67(1), 59-64.