TY - JOUR
T1 - Squamous cell carcinoma of the oral tongue
T2 - histopathological parameters associated with outcome
AU - Kolokythas, Antonia
AU - Park, S.
AU - Schlieve, T.
AU - Pytynia, K.
AU - Cox, D.
N1 - Publisher Copyright:
© 2015 International Association of Oral and Maxillofacial Surgeons.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Abstract The purpose of this study was to investigate the applicability of the histological risk assessment model proposed by Brandwein-Gensler et al. in a cohort of oral tongue squamous cell carcinoma (OTSCC) patients treated with definitive surgery. We also examined the impact of additional histopathological features on disease acceleration. The cases of 49 OTSCC patients attending our institution between 1995 and 2009, who underwent definitive surgical resection followed by adjunct chemoradiotherapy when indicated, were reviewed retrospectively. Surgical resection specimens and complete clinical and demographic data were available for these patients; follow-up was at least 6 months. In this cohort we only identified a correlation between gender and the histopathological risk model score (P < 0.001). With regard to clinical and demographic data, histopathological parameters, and disease status at last follow-up, we identified significant correlations between disease status and (1) grade of differentiation (P = 0.0086), and (2) keratin score (P = 0.026). We found no significant correlations between the histopathological risk assessment model and disease progression or outcomes, with the exception of gender (P < 0.0001). Grade of differentiation, keratin score, and the lymphocytic host response significantly impacted disease acceleration. For OTSCC, it appears that clinical characteristics of the tumour as well as histopathological markers play an important role in the outcome. Efforts towards identifying predictive markers should be continued, especially by sub-site of the oral cavity.
AB - Abstract The purpose of this study was to investigate the applicability of the histological risk assessment model proposed by Brandwein-Gensler et al. in a cohort of oral tongue squamous cell carcinoma (OTSCC) patients treated with definitive surgery. We also examined the impact of additional histopathological features on disease acceleration. The cases of 49 OTSCC patients attending our institution between 1995 and 2009, who underwent definitive surgical resection followed by adjunct chemoradiotherapy when indicated, were reviewed retrospectively. Surgical resection specimens and complete clinical and demographic data were available for these patients; follow-up was at least 6 months. In this cohort we only identified a correlation between gender and the histopathological risk model score (P < 0.001). With regard to clinical and demographic data, histopathological parameters, and disease status at last follow-up, we identified significant correlations between disease status and (1) grade of differentiation (P = 0.0086), and (2) keratin score (P = 0.026). We found no significant correlations between the histopathological risk assessment model and disease progression or outcomes, with the exception of gender (P < 0.0001). Grade of differentiation, keratin score, and the lymphocytic host response significantly impacted disease acceleration. For OTSCC, it appears that clinical characteristics of the tumour as well as histopathological markers play an important role in the outcome. Efforts towards identifying predictive markers should be continued, especially by sub-site of the oral cavity.
KW - histopathological markers
KW - oral tongue
KW - outcomes
KW - squamous cell carcinoma
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U2 - 10.1016/j.ijom.2015.01.027
DO - 10.1016/j.ijom.2015.01.027
M3 - Article
C2 - 26055524
AN - SCOPUS:84938740984
SN - 0901-5027
VL - 44
SP - 1069
EP - 1074
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 9
M1 - 3155
ER -