Plattenepitheliale läsionen der harnblase

Translated title of the contribution: Squamous cell lesions of the urinary bladder

S. Rausch, N. Gaisa, R. F. Youssef, Yair Lotan, A. Stenzl, T. Kälble

Research output: Contribution to journalArticle

Abstract

Background. Squamous cell carcinoma (SCC) and transitional carcinoma with squamous differentiation (SCC/TCC) are rare in western countries. Chronic inflammation and irritation of the urothelium are common risk factors for the development of SCC and TCC/SCC. Tumour biology of squamous cell cancer and precancerous squamous lesions is different from transitional cell cancer (TCC). Recent advances in molecular analysis of benign and malignant squamous cell lesions indicate that they are closely associated and might lead to improved bladder cancer subclassification in the future. Aim. At present, the clinical management and therapy of SCC remains challenging, as scientific evidence based on prospective clinical trials is not available. We performed an analysis of available literature on natural history, treatment, and prognosis of SCC, SCC/TCC and metaplastic lesions. Furthermore, recent findings in molecular cancer biology are discussed with a focus on their relevance for SCC carcinogenesis.

Original languageGerman
Pages (from-to)368-374
Number of pages7
JournalUrologe - Ausgabe A
Volume53
Issue number3
DOIs
StatePublished - 2014

Fingerprint

Squamous Cell Carcinoma
Urinary Bladder
Epithelial Cells
Neoplasms
Urothelium
Squamous Cell Neoplasms
Natural History
Urinary Bladder Neoplasms
Molecular Biology
Carcinogenesis
Clinical Trials
Inflammation

Keywords

  • Leukoplakia
  • Metaplasia
  • Squamous cell carcinoma
  • Therapy, adjuvant
  • Urothelial cancer

ASJC Scopus subject areas

  • Urology

Cite this

Rausch, S., Gaisa, N., Youssef, R. F., Lotan, Y., Stenzl, A., & Kälble, T. (2014). Plattenepitheliale läsionen der harnblase. Urologe - Ausgabe A, 53(3), 368-374. https://doi.org/10.1007/s00120-013-3406-z

Plattenepitheliale läsionen der harnblase. / Rausch, S.; Gaisa, N.; Youssef, R. F.; Lotan, Yair; Stenzl, A.; Kälble, T.

In: Urologe - Ausgabe A, Vol. 53, No. 3, 2014, p. 368-374.

Research output: Contribution to journalArticle

Rausch, S, Gaisa, N, Youssef, RF, Lotan, Y, Stenzl, A & Kälble, T 2014, 'Plattenepitheliale läsionen der harnblase', Urologe - Ausgabe A, vol. 53, no. 3, pp. 368-374. https://doi.org/10.1007/s00120-013-3406-z
Rausch S, Gaisa N, Youssef RF, Lotan Y, Stenzl A, Kälble T. Plattenepitheliale läsionen der harnblase. Urologe - Ausgabe A. 2014;53(3):368-374. https://doi.org/10.1007/s00120-013-3406-z
Rausch, S. ; Gaisa, N. ; Youssef, R. F. ; Lotan, Yair ; Stenzl, A. ; Kälble, T. / Plattenepitheliale läsionen der harnblase. In: Urologe - Ausgabe A. 2014 ; Vol. 53, No. 3. pp. 368-374.
@article{5a17920e9a744637bd41d27db7294e2a,
title = "Plattenepitheliale l{\"a}sionen der harnblase",
abstract = "Background. Squamous cell carcinoma (SCC) and transitional carcinoma with squamous differentiation (SCC/TCC) are rare in western countries. Chronic inflammation and irritation of the urothelium are common risk factors for the development of SCC and TCC/SCC. Tumour biology of squamous cell cancer and precancerous squamous lesions is different from transitional cell cancer (TCC). Recent advances in molecular analysis of benign and malignant squamous cell lesions indicate that they are closely associated and might lead to improved bladder cancer subclassification in the future. Aim. At present, the clinical management and therapy of SCC remains challenging, as scientific evidence based on prospective clinical trials is not available. We performed an analysis of available literature on natural history, treatment, and prognosis of SCC, SCC/TCC and metaplastic lesions. Furthermore, recent findings in molecular cancer biology are discussed with a focus on their relevance for SCC carcinogenesis.",
keywords = "Leukoplakia, Metaplasia, Squamous cell carcinoma, Therapy, adjuvant, Urothelial cancer",
author = "S. Rausch and N. Gaisa and Youssef, {R. F.} and Yair Lotan and A. Stenzl and T. K{\"a}lble",
year = "2014",
doi = "10.1007/s00120-013-3406-z",
language = "German",
volume = "53",
pages = "368--374",
journal = "Der Urologe",
issn = "0340-2592",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Plattenepitheliale läsionen der harnblase

AU - Rausch, S.

AU - Gaisa, N.

AU - Youssef, R. F.

AU - Lotan, Yair

AU - Stenzl, A.

AU - Kälble, T.

PY - 2014

Y1 - 2014

N2 - Background. Squamous cell carcinoma (SCC) and transitional carcinoma with squamous differentiation (SCC/TCC) are rare in western countries. Chronic inflammation and irritation of the urothelium are common risk factors for the development of SCC and TCC/SCC. Tumour biology of squamous cell cancer and precancerous squamous lesions is different from transitional cell cancer (TCC). Recent advances in molecular analysis of benign and malignant squamous cell lesions indicate that they are closely associated and might lead to improved bladder cancer subclassification in the future. Aim. At present, the clinical management and therapy of SCC remains challenging, as scientific evidence based on prospective clinical trials is not available. We performed an analysis of available literature on natural history, treatment, and prognosis of SCC, SCC/TCC and metaplastic lesions. Furthermore, recent findings in molecular cancer biology are discussed with a focus on their relevance for SCC carcinogenesis.

AB - Background. Squamous cell carcinoma (SCC) and transitional carcinoma with squamous differentiation (SCC/TCC) are rare in western countries. Chronic inflammation and irritation of the urothelium are common risk factors for the development of SCC and TCC/SCC. Tumour biology of squamous cell cancer and precancerous squamous lesions is different from transitional cell cancer (TCC). Recent advances in molecular analysis of benign and malignant squamous cell lesions indicate that they are closely associated and might lead to improved bladder cancer subclassification in the future. Aim. At present, the clinical management and therapy of SCC remains challenging, as scientific evidence based on prospective clinical trials is not available. We performed an analysis of available literature on natural history, treatment, and prognosis of SCC, SCC/TCC and metaplastic lesions. Furthermore, recent findings in molecular cancer biology are discussed with a focus on their relevance for SCC carcinogenesis.

KW - Leukoplakia

KW - Metaplasia

KW - Squamous cell carcinoma

KW - Therapy, adjuvant

KW - Urothelial cancer

UR - http://www.scopus.com/inward/record.url?scp=84898547502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84898547502&partnerID=8YFLogxK

U2 - 10.1007/s00120-013-3406-z

DO - 10.1007/s00120-013-3406-z

M3 - Article

C2 - 24549798

AN - SCOPUS:84898547502

VL - 53

SP - 368

EP - 374

JO - Der Urologe

JF - Der Urologe

SN - 0340-2592

IS - 3

ER -