SRD5A3: A Surprising Role in Glycosylation

Ashlee R. Stiles, David W. Russell

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The steroid 5α-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
JournalCell
Volume142
Issue number2
DOIs
StatePublished - Jul 2010

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Steroid hormones
Glycosylation
Oxidoreductases
Steroids
Sexual Development
Enzymes
Rare Diseases
Proteins
Hormones
Mutation
polyprenol reductase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

SRD5A3 : A Surprising Role in Glycosylation. / Stiles, Ashlee R.; Russell, David W.

In: Cell, Vol. 142, No. 2, 07.2010, p. 196-198.

Research output: Contribution to journalArticle

Stiles, Ashlee R. ; Russell, David W. / SRD5A3 : A Surprising Role in Glycosylation. In: Cell. 2010 ; Vol. 142, No. 2. pp. 196-198.
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