SRD5A3: A Surprising Role in Glycosylation

Ashlee R. Stiles, David W. Russell

Research output: Contribution to journalShort survey

28 Scopus citations

Abstract

The steroid 5α-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
JournalCell
Volume142
Issue number2
DOIs
StatePublished - Jul 1 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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