SRD5A3: A Surprising Role in Glycosylation

Ashlee R. Stiles; David W. Russell

doi:10.1016/j.cell.2010.07.003

SRD5A3: A Surprising Role in Glycosylation

Ashlee R. Stiles, David W. Russell

Molecular Genetics

Research output: Contribution to journal › Short survey › peer-review

45 Scopus citations

Abstract

The steroid 5α-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

Original language	English (US)
Pages (from-to)	196-198
Number of pages	3
Journal	Cell
Volume	142
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2010.07.003
State	Published - Jul 2010

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2010.07.003

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title = "SRD5A3: A Surprising Role in Glycosylation",

abstract = "The steroid 5α-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.",

author = "Stiles, {Ashlee R.} and Russell, {David W.}",

year = "2010",

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AU - Russell, David W.

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AB - The steroid 5α-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

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SRD5A3: A Surprising Role in Glycosylation

Abstract

ASJC Scopus subject areas

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