SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity. In this review, we summarize the recent findings that contribute to the current understanding of the regulation of SREBPs and their physiologic roles in maintenance of lipid homeostasis, insulin signaling, innate immunity, and cancer development.

Original languageEnglish (US)
Pages (from-to)358-368
Number of pages11
JournalTrends in biochemical sciences
Volume43
Issue number5
DOIs
StatePublished - May 2018

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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