SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity. In this review, we summarize the recent findings that contribute to the current understanding of the regulation of SREBPs and their physiologic roles in maintenance of lipid homeostasis, insulin signaling, innate immunity, and cancer development.

Original languageEnglish (US)
JournalTrends in Biochemical Sciences
DOIs
StateAccepted/In press - Jan 1 2018

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Sterol Regulatory Element Binding Proteins
Lipid Metabolism
Insulin
Gene encoding
Unsaturated Fatty Acids
Innate Immunity
Transcriptional Activation
Homeostasis
Transcription Factors
Thermodynamic properties
Chemical activation
Cholesterol
Maintenance
Membranes
Lipids
Messenger RNA
Enzymes
Genes
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

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