TY - JOUR
T1 - SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond
AU - DeBose-Boyd, Russell A.
AU - Ye, Jin
N1 - Funding Information:
Authors are supported by grants from the National Institutes of Health (HL020948 to R.A.D-B. and J.Y.; GM112409 to R.A.D-B., and GM116106 to J.Y.) and the Welch Foundation (I-1832).
Funding Information:
Authors are supported by grants from the National Institutes of Health ( HL020948 to R.A.D-B. and J.Y.; GM112409 to R.A.D-B., and GM116106 to J.Y.) and the Welch Foundation ( I-1832 ).
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/5
Y1 - 2018/5
N2 - Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity. In this review, we summarize the recent findings that contribute to the current understanding of the regulation of SREBPs and their physiologic roles in maintenance of lipid homeostasis, insulin signaling, innate immunity, and cancer development.
AB - Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that activate genes encoding enzymes required for synthesis of cholesterol and unsaturated fatty acids. SREBPs are controlled by multiple mechanisms at the level of mRNA synthesis, proteolytic activation, and transcriptional activity. In this review, we summarize the recent findings that contribute to the current understanding of the regulation of SREBPs and their physiologic roles in maintenance of lipid homeostasis, insulin signaling, innate immunity, and cancer development.
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U2 - 10.1016/j.tibs.2018.01.005
DO - 10.1016/j.tibs.2018.01.005
M3 - Review article
C2 - 29500098
AN - SCOPUS:85042609626
SN - 0968-0004
VL - 43
SP - 358
EP - 368
JO - Trends in biochemical sciences
JF - Trends in biochemical sciences
IS - 5
ER -