@article{fe8b6fffc3384a1a8c539192db354b0b,
title = "Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers",
abstract = "Objectives: There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders. Methods: N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests. We examined temporal reliability across 1 week and stability via three consecutive assessments. Consistency of assessment by the study rater (intrarater reliability) was calculated using the data from the second and third of these consecutive assessments. Results: Test–retest reliability correlations varied between Pearson's r = 0.75 and 0.8. Intrarater reliability between 0.7 and 0.93. Stability for the primary measure for each test yielded within-subject standard deviation values between 5.9 and 11.23 for accuracy measures and 0.735 and 17.3 seconds for latency measures. Convergent validity for three tasks was in the acceptable range, but low for the Symbol Check task. Conclusions: Analysis shows high levels of reliability and stability. Levels of convergent validity were modest but acceptable in the case of all but one test.",
keywords = "cognition, depression, memory, neuropsychological, screening",
author = "Harrison, {John E.} and Harry Barry and Baune, {Bernhard T.} and Best, {Michael W.} and Bowie, {Christopher R.} and Cha, {Danielle S.} and Larry Culpepper and Philippe Fossati and Greer, {Tracy L.} and Catherine Harmer and Esther Klag and Lam, {Raymond W.} and Yena Lee and Mansur, {Rodrigo B.} and Wittchen, {Hans Ulrich} and McIntyre, {Roger S.}",
note = "Funding Information: In addition to receipt of funding from Lundbeck for the present study, Dr. McIntyre has received grants and personal fees from Lundbeck, Pfizer, AstraZeneca, JanssenOrtho, Purdue, Otsuka, Shire, Allergan; and personal fees from Eli‐Lilly, Johnson & Johnson, Moksha8, Sunovion, Mitsubishi, Takeda, Forest, and Bristol‐Myers Squibb. Funding Information: Dr. Bowie is a consultant for Lundbeck, Takeda, Otsuka, and Boerhinger Ingelheim and has received grant support from Pfizer, Takeda, and Lundbeck. Funding Information: Dr. Fossati has received grants from Servier and honoraria from Servier, Janssen, and Lundbeck. Funding Information: Dr. Greer has received research funding from NARSAD and honoraria and/or consulting fees from H. Lundbeck A/S and Takeda. Funding Information: Dr. Harmer has received consultancy fees from Lundbeck, P1vital, Ono Pharmeceuticals, and Johnson & Johnson, as well as grant funding from UCB, Johnson & Johnson, Lundbeck, and Sunovion. Funding Information: Dr. Lam has received speakers fees from AstraZeneca, Canadian Network for Mood and Anxiety Treatments, Canadian Psychiatric Association, Lundbeck, Lundbeck Institute, and Otsuka; consultancy fees from Allergan, Asia‐Pacific Economic Cooperation, Bristol Myers Squibb, Canadian Depression Research and Intervention Network, Canadian Network for Mood and Anxiety Treatments, Janssen, Lundbeck, Medscape, Pfizer, Takeda; research funds from BC Leading Edge Foundation, Brain Canada, Bristol Myers Squibb, Canadian Institutes of Health Research, Canadian Depression Research and Intervention Network, Canadian Network for Mood and Anxiety Treatments, Janssen, Lundbeck, Movember Foundation, Pfizer, St. Jude Medical, University Health Network Foundation, Vancouver Coastal Health Research Institute, VGH Foundation. In addition, Dr. Lam owns the copyright to the Lam Employment Absence and Productivity Scale (LEAPS). Funding Information: Dr. Mansur reports fellowship funding from Lundbeck outside the submitted work. Dr. Wittchen reports honoraria from Lundbeck.",
year = "2018",
month = sep,
doi = "10.1002/mpr.1736",
language = "English (US)",
volume = "27",
journal = "International Journal of Methods in Psychiatric Research",
issn = "1049-8931",
publisher = "John Wiley and Sons Ltd",
number = "3",
}