Abstract
Objectives: There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders. Methods: N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests. We examined temporal reliability across 1 week and stability via three consecutive assessments. Consistency of assessment by the study rater (intrarater reliability) was calculated using the data from the second and third of these consecutive assessments. Results: Test–retest reliability correlations varied between Pearson's r = 0.75 and 0.8. Intrarater reliability between 0.7 and 0.93. Stability for the primary measure for each test yielded within-subject standard deviation values between 5.9 and 11.23 for accuracy measures and 0.735 and 17.3 seconds for latency measures. Convergent validity for three tasks was in the acceptable range, but low for the Symbol Check task. Conclusions: Analysis shows high levels of reliability and stability. Levels of convergent validity were modest but acceptable in the case of all but one test.
| Original language | English (US) |
|---|---|
| Article number | e1736 |
| Journal | International Journal of Methods in Psychiatric Research |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1 2018 |
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Keywords
- cognition
- depression
- memory
- neuropsychological
- screening
ASJC Scopus subject areas
- Psychiatry and Mental health
Cite this
Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression : A psychometric exploration in healthy volunteers. / Harrison, John E.; Barry, Harry; Baune, Bernhard T.; Best, Michael W.; Bowie, Christopher R.; Cha, Danielle S.; Culpepper, Larry; Fossati, Philippe; Greer, Tracy L.; Harmer, Catherine; Klag, Esther; Lam, Raymond W.; Lee, Yena; Mansur, Rodrigo B.; Wittchen, Hans Ulrich; McIntyre, Roger S.
In: International Journal of Methods in Psychiatric Research, Vol. 27, No. 3, e1736, 01.09.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression
T2 - A psychometric exploration in healthy volunteers
AU - Harrison, John E.
AU - Barry, Harry
AU - Baune, Bernhard T.
AU - Best, Michael W.
AU - Bowie, Christopher R.
AU - Cha, Danielle S.
AU - Culpepper, Larry
AU - Fossati, Philippe
AU - Greer, Tracy L.
AU - Harmer, Catherine
AU - Klag, Esther
AU - Lam, Raymond W.
AU - Lee, Yena
AU - Mansur, Rodrigo B.
AU - Wittchen, Hans Ulrich
AU - McIntyre, Roger S.
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Objectives: There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders. Methods: N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests. We examined temporal reliability across 1 week and stability via three consecutive assessments. Consistency of assessment by the study rater (intrarater reliability) was calculated using the data from the second and third of these consecutive assessments. Results: Test–retest reliability correlations varied between Pearson's r = 0.75 and 0.8. Intrarater reliability between 0.7 and 0.93. Stability for the primary measure for each test yielded within-subject standard deviation values between 5.9 and 11.23 for accuracy measures and 0.735 and 17.3 seconds for latency measures. Convergent validity for three tasks was in the acceptable range, but low for the Symbol Check task. Conclusions: Analysis shows high levels of reliability and stability. Levels of convergent validity were modest but acceptable in the case of all but one test.
AB - Objectives: There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders. Methods: N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests. We examined temporal reliability across 1 week and stability via three consecutive assessments. Consistency of assessment by the study rater (intrarater reliability) was calculated using the data from the second and third of these consecutive assessments. Results: Test–retest reliability correlations varied between Pearson's r = 0.75 and 0.8. Intrarater reliability between 0.7 and 0.93. Stability for the primary measure for each test yielded within-subject standard deviation values between 5.9 and 11.23 for accuracy measures and 0.735 and 17.3 seconds for latency measures. Convergent validity for three tasks was in the acceptable range, but low for the Symbol Check task. Conclusions: Analysis shows high levels of reliability and stability. Levels of convergent validity were modest but acceptable in the case of all but one test.
KW - cognition
KW - depression
KW - memory
KW - neuropsychological
KW - screening
UR - http://www.scopus.com/inward/record.url?scp=85052711814&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052711814&partnerID=8YFLogxK
U2 - 10.1002/mpr.1736
DO - 10.1002/mpr.1736
M3 - Article
C2 - 30088298
AN - SCOPUS:85052711814
VL - 27
JO - International Journal of Methods in Psychiatric Research
JF - International Journal of Methods in Psychiatric Research
SN - 1049-8931
IS - 3
M1 - e1736
ER -