Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery

Michael Rink, Behfar Ehdaie, Eugene K. Cha, David A. Green, Pierre I. Karakiewicz, Marko Babjuk, Vitaly Margulis, Jay D. Raman, Robert S. Svatek, Harun Fajkovic, Richard K. Lee, Giacomo Novara, Jens Hansen, Siamak Daneshmand, Yair Lotan, Wassim Kassouf, Hans Martin Fritsche, Armin Pycha, Margit Fisch, Douglas S. ScherrShahrokh F. Shariat

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Dissimilarities in management and outcomes exist between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). Objective: The aim of this study was to analyze the stage-specific impact of upper or lower urinary tract tumor location on oncologic outcomes. Design, setting, and participants: Data were collected from 4335 patients with UCB treated with radical cystectomy (RC) and bilateral pelvic lymphadenectomy (PLND), 877 patients with ureteral UTUC, and 1615 with pelvicalyceal UTUC treated with radical nephroureterectomy (RNU). No patient received preoperative chemotherapy or radiation therapy. Interventions: Patients were treated with RC and bilateral PLND or RNU. Measurements: Outcomes were assessed according to primary tumor location. Results and limitations: Compared to UTUC patients, UCB patients had more advanced tumor stage and higher grade, and they were more likely to harbor lymphovascular invasion (LVI) and lymph node metastasis (p < 0.001). In non-muscle-invasive tumor stages, UCB patients were more likely to experience disease recurrence and mortality compared to renal pelvicalyceal tumor patients (p < 0.002) but not ureteral tumors (p > 0.05). In pT2 and pT3 tumors, there was no difference in outcomes between the three tumor locations. In pT4 tumors, patients with ureteral and pelvicalyceal tumors were more likely to experience disease recurrence and mortality compared to UCB patients (p < 0.004). These stage-specific findings were unchanged after adjustment for the effects of age, gender, tumor grade, LVI, lymph node status, and adjuvant chemotherapy. This study is limited by its retrospective and multicenter nature. Conclusions: Stage-specific differences in outcomes exist between UCB and UTUC. The differentially worse outcomes by stage between UCB and UTUC patients underline the differences between both cancer entities and the need for individualized stage-specific management for each patient.

Original languageEnglish (US)
Pages (from-to)677-684
Number of pages8
JournalEuropean Urology
Volume62
Issue number4
DOIs
StatePublished - Oct 2012

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Carcinoma
Neoplasms
Urinary Bladder
Cystectomy
Lymph Nodes
Adjuvant Chemotherapy
Lymph Node Excision
Urinary Tract
Radiotherapy
Neoplasm Metastasis
Recurrence
Drug Therapy
Mortality

Keywords

  • Bladder cancer
  • Prognosis
  • Radical cystectomy
  • Radical nephroureterectomy
  • Survival
  • Transitional cell carcinoma
  • Upper tract urothelial carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery. / Rink, Michael; Ehdaie, Behfar; Cha, Eugene K.; Green, David A.; Karakiewicz, Pierre I.; Babjuk, Marko; Margulis, Vitaly; Raman, Jay D.; Svatek, Robert S.; Fajkovic, Harun; Lee, Richard K.; Novara, Giacomo; Hansen, Jens; Daneshmand, Siamak; Lotan, Yair; Kassouf, Wassim; Fritsche, Hans Martin; Pycha, Armin; Fisch, Margit; Scherr, Douglas S.; Shariat, Shahrokh F.

In: European Urology, Vol. 62, No. 4, 10.2012, p. 677-684.

Research output: Contribution to journalArticle

Rink, M, Ehdaie, B, Cha, EK, Green, DA, Karakiewicz, PI, Babjuk, M, Margulis, V, Raman, JD, Svatek, RS, Fajkovic, H, Lee, RK, Novara, G, Hansen, J, Daneshmand, S, Lotan, Y, Kassouf, W, Fritsche, HM, Pycha, A, Fisch, M, Scherr, DS & Shariat, SF 2012, 'Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery', European Urology, vol. 62, no. 4, pp. 677-684. https://doi.org/10.1016/j.eururo.2012.02.018
Rink, Michael ; Ehdaie, Behfar ; Cha, Eugene K. ; Green, David A. ; Karakiewicz, Pierre I. ; Babjuk, Marko ; Margulis, Vitaly ; Raman, Jay D. ; Svatek, Robert S. ; Fajkovic, Harun ; Lee, Richard K. ; Novara, Giacomo ; Hansen, Jens ; Daneshmand, Siamak ; Lotan, Yair ; Kassouf, Wassim ; Fritsche, Hans Martin ; Pycha, Armin ; Fisch, Margit ; Scherr, Douglas S. ; Shariat, Shahrokh F. / Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery. In: European Urology. 2012 ; Vol. 62, No. 4. pp. 677-684.
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abstract = "Background: Dissimilarities in management and outcomes exist between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). Objective: The aim of this study was to analyze the stage-specific impact of upper or lower urinary tract tumor location on oncologic outcomes. Design, setting, and participants: Data were collected from 4335 patients with UCB treated with radical cystectomy (RC) and bilateral pelvic lymphadenectomy (PLND), 877 patients with ureteral UTUC, and 1615 with pelvicalyceal UTUC treated with radical nephroureterectomy (RNU). No patient received preoperative chemotherapy or radiation therapy. Interventions: Patients were treated with RC and bilateral PLND or RNU. Measurements: Outcomes were assessed according to primary tumor location. Results and limitations: Compared to UTUC patients, UCB patients had more advanced tumor stage and higher grade, and they were more likely to harbor lymphovascular invasion (LVI) and lymph node metastasis (p < 0.001). In non-muscle-invasive tumor stages, UCB patients were more likely to experience disease recurrence and mortality compared to renal pelvicalyceal tumor patients (p < 0.002) but not ureteral tumors (p > 0.05). In pT2 and pT3 tumors, there was no difference in outcomes between the three tumor locations. In pT4 tumors, patients with ureteral and pelvicalyceal tumors were more likely to experience disease recurrence and mortality compared to UCB patients (p < 0.004). These stage-specific findings were unchanged after adjustment for the effects of age, gender, tumor grade, LVI, lymph node status, and adjuvant chemotherapy. This study is limited by its retrospective and multicenter nature. Conclusions: Stage-specific differences in outcomes exist between UCB and UTUC. The differentially worse outcomes by stage between UCB and UTUC patients underline the differences between both cancer entities and the need for individualized stage-specific management for each patient.",
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T1 - Stage-specific impact of tumor location on oncologic outcomes in patients with upper and lower tract urothelial carcinoma following radical surgery

AU - Rink, Michael

AU - Ehdaie, Behfar

AU - Cha, Eugene K.

AU - Green, David A.

AU - Karakiewicz, Pierre I.

AU - Babjuk, Marko

AU - Margulis, Vitaly

AU - Raman, Jay D.

AU - Svatek, Robert S.

AU - Fajkovic, Harun

AU - Lee, Richard K.

AU - Novara, Giacomo

AU - Hansen, Jens

AU - Daneshmand, Siamak

AU - Lotan, Yair

AU - Kassouf, Wassim

AU - Fritsche, Hans Martin

AU - Pycha, Armin

AU - Fisch, Margit

AU - Scherr, Douglas S.

AU - Shariat, Shahrokh F.

PY - 2012/10

Y1 - 2012/10

N2 - Background: Dissimilarities in management and outcomes exist between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). Objective: The aim of this study was to analyze the stage-specific impact of upper or lower urinary tract tumor location on oncologic outcomes. Design, setting, and participants: Data were collected from 4335 patients with UCB treated with radical cystectomy (RC) and bilateral pelvic lymphadenectomy (PLND), 877 patients with ureteral UTUC, and 1615 with pelvicalyceal UTUC treated with radical nephroureterectomy (RNU). No patient received preoperative chemotherapy or radiation therapy. Interventions: Patients were treated with RC and bilateral PLND or RNU. Measurements: Outcomes were assessed according to primary tumor location. Results and limitations: Compared to UTUC patients, UCB patients had more advanced tumor stage and higher grade, and they were more likely to harbor lymphovascular invasion (LVI) and lymph node metastasis (p < 0.001). In non-muscle-invasive tumor stages, UCB patients were more likely to experience disease recurrence and mortality compared to renal pelvicalyceal tumor patients (p < 0.002) but not ureteral tumors (p > 0.05). In pT2 and pT3 tumors, there was no difference in outcomes between the three tumor locations. In pT4 tumors, patients with ureteral and pelvicalyceal tumors were more likely to experience disease recurrence and mortality compared to UCB patients (p < 0.004). These stage-specific findings were unchanged after adjustment for the effects of age, gender, tumor grade, LVI, lymph node status, and adjuvant chemotherapy. This study is limited by its retrospective and multicenter nature. Conclusions: Stage-specific differences in outcomes exist between UCB and UTUC. The differentially worse outcomes by stage between UCB and UTUC patients underline the differences between both cancer entities and the need for individualized stage-specific management for each patient.

AB - Background: Dissimilarities in management and outcomes exist between upper tract urothelial carcinoma (UTUC) and urothelial carcinoma of the bladder (UCB). Objective: The aim of this study was to analyze the stage-specific impact of upper or lower urinary tract tumor location on oncologic outcomes. Design, setting, and participants: Data were collected from 4335 patients with UCB treated with radical cystectomy (RC) and bilateral pelvic lymphadenectomy (PLND), 877 patients with ureteral UTUC, and 1615 with pelvicalyceal UTUC treated with radical nephroureterectomy (RNU). No patient received preoperative chemotherapy or radiation therapy. Interventions: Patients were treated with RC and bilateral PLND or RNU. Measurements: Outcomes were assessed according to primary tumor location. Results and limitations: Compared to UTUC patients, UCB patients had more advanced tumor stage and higher grade, and they were more likely to harbor lymphovascular invasion (LVI) and lymph node metastasis (p < 0.001). In non-muscle-invasive tumor stages, UCB patients were more likely to experience disease recurrence and mortality compared to renal pelvicalyceal tumor patients (p < 0.002) but not ureteral tumors (p > 0.05). In pT2 and pT3 tumors, there was no difference in outcomes between the three tumor locations. In pT4 tumors, patients with ureteral and pelvicalyceal tumors were more likely to experience disease recurrence and mortality compared to UCB patients (p < 0.004). These stage-specific findings were unchanged after adjustment for the effects of age, gender, tumor grade, LVI, lymph node status, and adjuvant chemotherapy. This study is limited by its retrospective and multicenter nature. Conclusions: Stage-specific differences in outcomes exist between UCB and UTUC. The differentially worse outcomes by stage between UCB and UTUC patients underline the differences between both cancer entities and the need for individualized stage-specific management for each patient.

KW - Bladder cancer

KW - Prognosis

KW - Radical cystectomy

KW - Radical nephroureterectomy

KW - Survival

KW - Transitional cell carcinoma

KW - Upper tract urothelial carcinoma

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