Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling

Zhong Min Dai, Shuhui Sun, Chunyang Wang, Hao Huang, Xuemei Hu, Zunyi Zhang, Qing Richard Lu, Mengsheng Qiu

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Oligodendrocytes are myelin-forming glia that ensheath the axons of neurons in the CNS. Recent studies have revealed that Wnt/β-catenin signaling plays important roles in oligodendrocyte development and myelin formation. However, there are conflicting reports on the specific function of Wnt signaling components in oligodendrocyte specification and differentiation. In the present study, we demonstrate that activation of β-catenin in neural progenitor cells before gliogenesis inhibits the generation of oligodendrocyte progenitors (OLPs) in mice. Once OLPs are formed, β-catenin becomes necessary for oligodendrocyte differentiation. Disruption of β-catenin signaling instead leads to a significant delay of oligodendrocyte maturation. These findings suggest that Wnt/β-catenin pathway regulates oligodendrocyte development in a stage-dependent manner.

Original languageEnglish (US)
Pages (from-to)8467-8473
Number of pages7
JournalJournal of Neuroscience
Volume34
Issue number25
DOIs
StatePublished - 2014

Fingerprint

Catenins
Oligodendroglia
Myelin Sheath
Wnt Signaling Pathway
Neuroglia
Axons
Stem Cells
Neurons

Keywords

  • Oligodendrocyte differentiation
  • OLPs
  • Spinal cord
  • Wnt
  • β-catenin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dai, Z. M., Sun, S., Wang, C., Huang, H., Hu, X., Zhang, Z., ... Qiu, M. (2014). Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling. Journal of Neuroscience, 34(25), 8467-8473. https://doi.org/10.1523/JNEUROSCI.0311-14.2014

Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling. / Dai, Zhong Min; Sun, Shuhui; Wang, Chunyang; Huang, Hao; Hu, Xuemei; Zhang, Zunyi; Lu, Qing Richard; Qiu, Mengsheng.

In: Journal of Neuroscience, Vol. 34, No. 25, 2014, p. 8467-8473.

Research output: Contribution to journalArticle

Dai, ZM, Sun, S, Wang, C, Huang, H, Hu, X, Zhang, Z, Lu, QR & Qiu, M 2014, 'Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling', Journal of Neuroscience, vol. 34, no. 25, pp. 8467-8473. https://doi.org/10.1523/JNEUROSCI.0311-14.2014
Dai, Zhong Min ; Sun, Shuhui ; Wang, Chunyang ; Huang, Hao ; Hu, Xuemei ; Zhang, Zunyi ; Lu, Qing Richard ; Qiu, Mengsheng. / Stage-specific regulation of oligodendrocyte development by Wnt/β-catenin signaling. In: Journal of Neuroscience. 2014 ; Vol. 34, No. 25. pp. 8467-8473.
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