Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions

Capability for lesion characterization-iLEAD study

iLEAD study group

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To determine the lesion characterization capability by low dose CT for localized lung lesions in comparison with standard dose CT. Subjects and methods: Approval for this study was granted by our Institutional Review Board. Fifty-two consecutive patients (36 males and 16 females, median age of 71 years.) who had CT examinations for evaluation of lung lesions comprise the study population. Two chest CT scans were performed with current time product of 50 and 150 mAs at 120 kVp, with the same scan length with a 16 detector-row CT scanner. Three readers evaluated 52 target lesions and assigned an overall impression score to each target lesion, using a 5 point scale from 1 (definitely benign) to 5 (definitely malignant). Six features of the lesions including lesion type, margin characteristics, calcification, lobulation, speculation, and pleural indentation were also reported with 5-point scales. The weighted kappa analyses and receiver operating characteristic analysis were used for analysis. Results: The mean kappa value between low-and standard-dose CT was 0.82 for overall impression of the lesions, showing almost perfect agreement. Area under the curve of low-dose CT (Az = 0.74) had no significant difference from that of standard-dose CT (Az = 0.74) (p = 0.61). The kappa values for six lesion features ranged from 0.45 to 0.83, showing moderate to almost perfect agreement. Conclusion: Lesion characterization capability by low-dose CT images was comparable to that by standard-dose CT images and therefore sufficient for evaluation of localized lung lesions.

Original languageEnglish (US)
Pages (from-to)67-73
Number of pages7
JournalEuropean Journal of Radiology Open
Volume3
DOIs
StatePublished - 2016

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Lung
Research Ethics Committees
ROC Curve
Area Under Curve
Thorax
CT protocol
Population

Keywords

  • Chest CT
  • Lung masses
  • Lung nodules
  • Radiation dose reduction

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

@article{8d40e8f164d74ab8ab411a454f516180,
title = "Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions: Capability for lesion characterization-iLEAD study",
abstract = "Objective: To determine the lesion characterization capability by low dose CT for localized lung lesions in comparison with standard dose CT. Subjects and methods: Approval for this study was granted by our Institutional Review Board. Fifty-two consecutive patients (36 males and 16 females, median age of 71 years.) who had CT examinations for evaluation of lung lesions comprise the study population. Two chest CT scans were performed with current time product of 50 and 150 mAs at 120 kVp, with the same scan length with a 16 detector-row CT scanner. Three readers evaluated 52 target lesions and assigned an overall impression score to each target lesion, using a 5 point scale from 1 (definitely benign) to 5 (definitely malignant). Six features of the lesions including lesion type, margin characteristics, calcification, lobulation, speculation, and pleural indentation were also reported with 5-point scales. The weighted kappa analyses and receiver operating characteristic analysis were used for analysis. Results: The mean kappa value between low-and standard-dose CT was 0.82 for overall impression of the lesions, showing almost perfect agreement. Area under the curve of low-dose CT (Az = 0.74) had no significant difference from that of standard-dose CT (Az = 0.74) (p = 0.61). The kappa values for six lesion features ranged from 0.45 to 0.83, showing moderate to almost perfect agreement. Conclusion: Lesion characterization capability by low-dose CT images was comparable to that by standard-dose CT images and therefore sufficient for evaluation of localized lung lesions.",
keywords = "Chest CT, Lung masses, Lung nodules, Radiation dose reduction",
author = "{iLEAD study group} and Takeshi Kubo and Yoshiharu Ohno and Daisuke Takenaka and Mizuki Nishino and Shiva Gautam and Kazuro Sugimura and Kauczor, {Hans Ulrich} and Hiroto Hatabu and Lin, {Pei Jan P} and Masaya Takahashi and Arkadiusz Sitek and Munenobu Nogami and Hisanobu Koyama and Julia Ley-Zaporozhan and Wolfram Stiller and Sebastian Ley and Hiroyasu Inokawa and Yasuko Fujisawa and Hiroyuki Kura and Vassilios Raptopoulos",
year = "2016",
doi = "10.1016/j.ejro.2016.03.002",
language = "English (US)",
volume = "3",
pages = "67--73",
journal = "European Journal of Radiology Open",
issn = "2352-0477",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions

T2 - Capability for lesion characterization-iLEAD study

AU - iLEAD study group

AU - Kubo, Takeshi

AU - Ohno, Yoshiharu

AU - Takenaka, Daisuke

AU - Nishino, Mizuki

AU - Gautam, Shiva

AU - Sugimura, Kazuro

AU - Kauczor, Hans Ulrich

AU - Hatabu, Hiroto

AU - Lin, Pei Jan P

AU - Takahashi, Masaya

AU - Sitek, Arkadiusz

AU - Nogami, Munenobu

AU - Koyama, Hisanobu

AU - Ley-Zaporozhan, Julia

AU - Stiller, Wolfram

AU - Ley, Sebastian

AU - Inokawa, Hiroyasu

AU - Fujisawa, Yasuko

AU - Kura, Hiroyuki

AU - Raptopoulos, Vassilios

PY - 2016

Y1 - 2016

N2 - Objective: To determine the lesion characterization capability by low dose CT for localized lung lesions in comparison with standard dose CT. Subjects and methods: Approval for this study was granted by our Institutional Review Board. Fifty-two consecutive patients (36 males and 16 females, median age of 71 years.) who had CT examinations for evaluation of lung lesions comprise the study population. Two chest CT scans were performed with current time product of 50 and 150 mAs at 120 kVp, with the same scan length with a 16 detector-row CT scanner. Three readers evaluated 52 target lesions and assigned an overall impression score to each target lesion, using a 5 point scale from 1 (definitely benign) to 5 (definitely malignant). Six features of the lesions including lesion type, margin characteristics, calcification, lobulation, speculation, and pleural indentation were also reported with 5-point scales. The weighted kappa analyses and receiver operating characteristic analysis were used for analysis. Results: The mean kappa value between low-and standard-dose CT was 0.82 for overall impression of the lesions, showing almost perfect agreement. Area under the curve of low-dose CT (Az = 0.74) had no significant difference from that of standard-dose CT (Az = 0.74) (p = 0.61). The kappa values for six lesion features ranged from 0.45 to 0.83, showing moderate to almost perfect agreement. Conclusion: Lesion characterization capability by low-dose CT images was comparable to that by standard-dose CT images and therefore sufficient for evaluation of localized lung lesions.

AB - Objective: To determine the lesion characterization capability by low dose CT for localized lung lesions in comparison with standard dose CT. Subjects and methods: Approval for this study was granted by our Institutional Review Board. Fifty-two consecutive patients (36 males and 16 females, median age of 71 years.) who had CT examinations for evaluation of lung lesions comprise the study population. Two chest CT scans were performed with current time product of 50 and 150 mAs at 120 kVp, with the same scan length with a 16 detector-row CT scanner. Three readers evaluated 52 target lesions and assigned an overall impression score to each target lesion, using a 5 point scale from 1 (definitely benign) to 5 (definitely malignant). Six features of the lesions including lesion type, margin characteristics, calcification, lobulation, speculation, and pleural indentation were also reported with 5-point scales. The weighted kappa analyses and receiver operating characteristic analysis were used for analysis. Results: The mean kappa value between low-and standard-dose CT was 0.82 for overall impression of the lesions, showing almost perfect agreement. Area under the curve of low-dose CT (Az = 0.74) had no significant difference from that of standard-dose CT (Az = 0.74) (p = 0.61). The kappa values for six lesion features ranged from 0.45 to 0.83, showing moderate to almost perfect agreement. Conclusion: Lesion characterization capability by low-dose CT images was comparable to that by standard-dose CT images and therefore sufficient for evaluation of localized lung lesions.

KW - Chest CT

KW - Lung masses

KW - Lung nodules

KW - Radiation dose reduction

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U2 - 10.1016/j.ejro.2016.03.002

DO - 10.1016/j.ejro.2016.03.002

M3 - Article

VL - 3

SP - 67

EP - 73

JO - European Journal of Radiology Open

JF - European Journal of Radiology Open

SN - 2352-0477

ER -