TY - JOUR
T1 - Standard-dose vs. low-dose CT protocols in the evaluation of localized lung lesions
T2 - Capability for lesion characterization-iLEAD study
AU - iLEAD study group
AU - Kubo, Takeshi
AU - Ohno, Yoshiharu
AU - Takenaka, Daisuke
AU - Nishino, Mizuki
AU - Gautam, Shiva
AU - Sugimura, Kazuro
AU - Kauczor, Hans Ulrich
AU - Hatabu, Hiroto
AU - Lin, Pei Jan P
AU - Takahashi, Masaya
AU - Sitek, Arkadiusz
AU - Nogami, Munenobu
AU - Koyama, Hisanobu
AU - Ley-Zaporozhan, Julia
AU - Stiller, Wolfram
AU - Ley, Sebastian
AU - Inokawa, Hiroyasu
AU - Fujisawa, Yasuko
AU - Kura, Hiroyuki
AU - Raptopoulos, Vassilios
N1 - Funding Information:
The study was supported by a research grant from Toshiba Medical Systems Corporation.
Publisher Copyright:
© 2016.
PY - 2016
Y1 - 2016
N2 - Objective: To determine the lesion characterization capability by low dose CT for localized lung lesions in comparison with standard dose CT. Subjects and methods: Approval for this study was granted by our Institutional Review Board. Fifty-two consecutive patients (36 males and 16 females, median age of 71 years.) who had CT examinations for evaluation of lung lesions comprise the study population. Two chest CT scans were performed with current time product of 50 and 150 mAs at 120 kVp, with the same scan length with a 16 detector-row CT scanner. Three readers evaluated 52 target lesions and assigned an overall impression score to each target lesion, using a 5 point scale from 1 (definitely benign) to 5 (definitely malignant). Six features of the lesions including lesion type, margin characteristics, calcification, lobulation, speculation, and pleural indentation were also reported with 5-point scales. The weighted kappa analyses and receiver operating characteristic analysis were used for analysis. Results: The mean kappa value between low-and standard-dose CT was 0.82 for overall impression of the lesions, showing almost perfect agreement. Area under the curve of low-dose CT (Az = 0.74) had no significant difference from that of standard-dose CT (Az = 0.74) (p = 0.61). The kappa values for six lesion features ranged from 0.45 to 0.83, showing moderate to almost perfect agreement. Conclusion: Lesion characterization capability by low-dose CT images was comparable to that by standard-dose CT images and therefore sufficient for evaluation of localized lung lesions.
AB - Objective: To determine the lesion characterization capability by low dose CT for localized lung lesions in comparison with standard dose CT. Subjects and methods: Approval for this study was granted by our Institutional Review Board. Fifty-two consecutive patients (36 males and 16 females, median age of 71 years.) who had CT examinations for evaluation of lung lesions comprise the study population. Two chest CT scans were performed with current time product of 50 and 150 mAs at 120 kVp, with the same scan length with a 16 detector-row CT scanner. Three readers evaluated 52 target lesions and assigned an overall impression score to each target lesion, using a 5 point scale from 1 (definitely benign) to 5 (definitely malignant). Six features of the lesions including lesion type, margin characteristics, calcification, lobulation, speculation, and pleural indentation were also reported with 5-point scales. The weighted kappa analyses and receiver operating characteristic analysis were used for analysis. Results: The mean kappa value between low-and standard-dose CT was 0.82 for overall impression of the lesions, showing almost perfect agreement. Area under the curve of low-dose CT (Az = 0.74) had no significant difference from that of standard-dose CT (Az = 0.74) (p = 0.61). The kappa values for six lesion features ranged from 0.45 to 0.83, showing moderate to almost perfect agreement. Conclusion: Lesion characterization capability by low-dose CT images was comparable to that by standard-dose CT images and therefore sufficient for evaluation of localized lung lesions.
KW - Chest CT
KW - Lung masses
KW - Lung nodules
KW - Radiation dose reduction
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U2 - 10.1016/j.ejro.2016.03.002
DO - 10.1016/j.ejro.2016.03.002
M3 - Article
C2 - 27957516
AN - SCOPUS:84961800967
SN - 2352-0477
VL - 3
SP - 67
EP - 73
JO - European Journal of Radiology Open
JF - European Journal of Radiology Open
ER -