TY - JOUR
T1 - Standardizing care to manage bleeding disorders in adolescents with heavy menses—A joint project from the ISTH pediatric/neonatal and women's health SSCs
AU - Zia, Ayesha
AU - Kouides, Peter
AU - Khodyakov, Dmitry
AU - Dao, Emily
AU - Lavin, Michelle
AU - Kadir, Rezan Abdul
AU - Othman, Maha
AU - Bauman, Dvora
AU - Halimeh, Susan
AU - Winikoff, Rochelle
AU - Revel-Vilk, Shoshana
N1 - Funding Information:
AZ is supported by a grant from the National Institutes of Health (1K23HL132054-01). This study was funded by an investigator-initiated grant (to AZ) by SHIRE US Inc, now a part of Takeda. The funding source was not involved in the study design, analysis, and interpretation of data; in the writing of the report; or the decision to submit the article for publication. The authors are indebted to the contribution of the international expert panel to work presented in this manuscript and thank the ISTH-SSC Neonatal/Pediatric and Women's Health Co-chairs, who provided additional comments and the UTSW Bleeding Disorders and Thrombosis team members who participated in the pilot panel run.
Funding Information:
AZ is supported by a grant from the National Institutes of Health (1K23HL132054‐01). This study was funded by an investigator‐initiated grant (to AZ) by SHIRE US Inc, now a part of Takeda. The funding source was not involved in the study design, analysis, and interpretation of data; in the writing of the report; or the decision to submit the article for publication.
Publisher Copyright:
© 2020 International Society on Thrombosis and Haemostasis
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Background: Bleeding disorders (BD) are under-recognized in adolescents with heavy menstrual bleeding (HMB). Objectives: The lack of clinical guidelines and variable symptomatic management of HMB created the imperative to standardize HMB care to identify and manage BD in adolescents. Methods: We convened an international working group (WG), utilized the results of a literature review to define knowledge gaps in HMB care, and used the collective clinical experience of the WG to develop care considerations for adolescents with BD and HMB. We then solicited input on the appropriateness of HMB care considerations from expert stakeholders representing hematology, adolescent medicine, and obstetrics-gynecology. We conducted an expert panel online, using the ExpertLens platform. During a three-round online modified-Delphi process, the expert panel rated the appropriateness of 21 care considerations using a 9-point scale to designate care as appropriate (7-9), uncertain (4-6), or inappropriate (1-3) covering screening for BD, the laboratory work-up, and management of adolescents with BD that present with HMB. We used the RAND/UCLA appropriateness method to determine the existence of consensus among the interdisciplinary panel of experts. Results: Thirty-nine experts participated in the panel. The experts rated fifteen HMB care considerations as appropriate, six as uncertain, and none as inappropriate. Conclusions: The HMB care statements represent the first set of HMB care considerations in adolescents with BD, developed with broad expert input on appropriateness. Although likely to be of interest to a range of clinicians who routinely manage adolescents with HMB, additional research is required in many key areas.
AB - Background: Bleeding disorders (BD) are under-recognized in adolescents with heavy menstrual bleeding (HMB). Objectives: The lack of clinical guidelines and variable symptomatic management of HMB created the imperative to standardize HMB care to identify and manage BD in adolescents. Methods: We convened an international working group (WG), utilized the results of a literature review to define knowledge gaps in HMB care, and used the collective clinical experience of the WG to develop care considerations for adolescents with BD and HMB. We then solicited input on the appropriateness of HMB care considerations from expert stakeholders representing hematology, adolescent medicine, and obstetrics-gynecology. We conducted an expert panel online, using the ExpertLens platform. During a three-round online modified-Delphi process, the expert panel rated the appropriateness of 21 care considerations using a 9-point scale to designate care as appropriate (7-9), uncertain (4-6), or inappropriate (1-3) covering screening for BD, the laboratory work-up, and management of adolescents with BD that present with HMB. We used the RAND/UCLA appropriateness method to determine the existence of consensus among the interdisciplinary panel of experts. Results: Thirty-nine experts participated in the panel. The experts rated fifteen HMB care considerations as appropriate, six as uncertain, and none as inappropriate. Conclusions: The HMB care statements represent the first set of HMB care considerations in adolescents with BD, developed with broad expert input on appropriateness. Although likely to be of interest to a range of clinicians who routinely manage adolescents with HMB, additional research is required in many key areas.
KW - adolescents
KW - bleeding disorders
KW - heavy menstrual bleeding
KW - hemostatic disorders
KW - menorrhagia
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U2 - 10.1111/jth.14974
DO - 10.1111/jth.14974
M3 - Article
C2 - 32573942
AN - SCOPUS:85091820148
SN - 1538-7933
VL - 18
SP - 2759
EP - 2774
JO - Journal of Thrombosis and Haemostasis
JF - Journal of Thrombosis and Haemostasis
IS - 10
ER -