Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia

Maria Labandeira-Rey; Florence Couzon; Sandrine Boisset; Eric L. Brown; Michele Bes; Yvonne Benito; Elena M. Barbu; Vanessa Vazquez; Magnus Höök; Jerome Etienne; François Vandenesch; M. Gabriela Bowden

doi:10.1126/science.1137165

Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia

Maria Labandeira-Rey, Florence Couzon, Sandrine Boisset, Eric L. Brown, Michele Bes, Yvonne Benito, Elena M. Barbu, Vanessa Vazquez, Magnus Höök, Jerome Etienne, François Vandenesch, M. Gabriela Bowden

Research output: Contribution to journal › Article › peer-review

626 Scopus citations

Abstract

The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).

Original language	English (US)
Pages (from-to)	1130-1133
Number of pages	4
Journal	Science
Volume	315
Issue number	5815
DOIs	https://doi.org/10.1126/science.1137165
State	Published - Feb 23 2007

ASJC Scopus subject areas

General

Access to Document

10.1126/science.1137165

Cite this

@article{8cd71c6907af41cf82676291d6fe1462,

title = "Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia",

abstract = "The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).",

author = "Maria Labandeira-Rey and Florence Couzon and Sandrine Boisset and Brown, {Eric L.} and Michele Bes and Yvonne Benito and Barbu, {Elena M.} and Vanessa Vazquez and Magnus H{\"o}{\"o}k and Jerome Etienne and Fran{\c c}ois Vandenesch and Bowden, {M. Gabriela}",

year = "2007",

month = feb,

day = "23",

doi = "10.1126/science.1137165",

language = "English (US)",

volume = "315",

pages = "1130--1133",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5815",

}

TY - JOUR

T1 - Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia

AU - Labandeira-Rey, Maria

AU - Couzon, Florence

AU - Boisset, Sandrine

AU - Brown, Eric L.

AU - Bes, Michele

AU - Benito, Yvonne

AU - Barbu, Elena M.

AU - Vazquez, Vanessa

AU - Höök, Magnus

AU - Etienne, Jerome

AU - Vandenesch, François

AU - Bowden, M. Gabriela

PY - 2007/2/23

Y1 - 2007/2/23

N2 - The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).

AB - The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).

UR - http://www.scopus.com/inward/record.url?scp=33847309856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847309856&partnerID=8YFLogxK

U2 - 10.1126/science.1137165

DO - 10.1126/science.1137165

M3 - Article

C2 - 17234914

AN - SCOPUS:33847309856

SN - 0036-8075

VL - 315

SP - 1130

EP - 1133

JO - Science

JF - Science

IS - 5815

ER -

Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this