State-of-the-Art: Hypo-responsiveness to Oral Antiplatelet Therapy in Patients with Type 2 Diabetes Mellitus

Dharam J Kumbhani; Steven P Marso; Carlos A. Alvarez; Darren K McGuire

doi:10.1007/s12170-014-0430-5

State-of-the-Art: Hypo-responsiveness to Oral Antiplatelet Therapy in Patients with Type 2 Diabetes Mellitus

Dharam J Kumbhani, Steven P Marso, Carlos A. Alvarez, Darren K McGuire

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Diabetes mellitus is a global pandemic, associated with a high burden of cardiovascular disease. There are multiple platelet derangements in patients with diabetes, and antiplatelet drugs remain the first-line agents for secondary prevention as well as for high-risk primary prevention among patients with diabetes. This review provides a summary of oral antiplatelet drug hypo-responsiveness in patients with diabetes, specifically aspirin and clopidogrel resistance. Topics discussed include antiplatelet testing, definitions used to define hypo-response and resistance, its prevalence, association with clinical outcomes, and strategies to mitigate resistance. The role of prasugrel and ticagrelor, as well as investigational agents, is also discussed.

Original language	English (US)
Journal	Current Cardiovascular Risk Reports
Volume	9
Issue number	2
DOIs	https://doi.org/10.1007/s12170-014-0430-5
State	Published - Feb 2015

Keywords

Antiplatelet
Antiplatelet resistance
Aspirin resistance
Clopidogrel resistance
Diabetes mellitus
High on-treatment platelet reactivity
Platelets

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1007/s12170-014-0430-5

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abstract = "Diabetes mellitus is a global pandemic, associated with a high burden of cardiovascular disease. There are multiple platelet derangements in patients with diabetes, and antiplatelet drugs remain the first-line agents for secondary prevention as well as for high-risk primary prevention among patients with diabetes. This review provides a summary of oral antiplatelet drug hypo-responsiveness in patients with diabetes, specifically aspirin and clopidogrel resistance. Topics discussed include antiplatelet testing, definitions used to define hypo-response and resistance, its prevalence, association with clinical outcomes, and strategies to mitigate resistance. The role of prasugrel and ticagrelor, as well as investigational agents, is also discussed.",

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