@article{64894e7a88c244f980ce42ac653e5ccc,
title = "State-of-the-Art: Hypo-responsiveness to Oral Antiplatelet Therapy in Patients with Type 2 Diabetes Mellitus",
abstract = "Diabetes mellitus is a global pandemic, associated with a high burden of cardiovascular disease. There are multiple platelet derangements in patients with diabetes, and antiplatelet drugs remain the first-line agents for secondary prevention as well as for high-risk primary prevention among patients with diabetes. This review provides a summary of oral antiplatelet drug hypo-responsiveness in patients with diabetes, specifically aspirin and clopidogrel resistance. Topics discussed include antiplatelet testing, definitions used to define hypo-response and resistance, its prevalence, association with clinical outcomes, and strategies to mitigate resistance. The role of prasugrel and ticagrelor, as well as investigational agents, is also discussed.",
keywords = "Antiplatelet, Antiplatelet resistance, Aspirin resistance, Clopidogrel resistance, Diabetes mellitus, High on-treatment platelet reactivity, Platelets",
author = "Kumbhani, {Dharam J} and Marso, {Steven P} and Alvarez, {Carlos A.} and McGuire, {Darren K}",
note = "Funding Information: Carlos Alvarez received grants from the NIH. Dharam Kumbhani has no disclosures. Steven Marso received grants and personal fees and non-financial support from Novo Nordisk. Marso received grants and personal fees from St. Jude Medical, Terumo and The Medicine Company. Marso also received grants from Astra Zeneca and Bristol Myers Squibb. Darren McGuire received research grant support and personal fees and non-financial support from Novo Nordisk, Astra Zeneca, Bristol Myers Squibb, GlaxoSmithKline, The Medicines Company, Takeda Pharmaceuticals, Janssen, Eli Lilly, Boehringer Ingelheim, Merck, Regeneron, Lexicon, and Sanofi Aventis. Funding Information: Dr. Alvarez{\textquoteright}s effort was supported by NIH grant K08DK101602. Publisher Copyright: {\textcopyright} 2015, Springer Science+Business Media New York.",
year = "2015",
month = feb,
doi = "10.1007/s12170-014-0430-5",
language = "English (US)",
volume = "9",
journal = "Current Cardiovascular Risk Reports",
issn = "1932-9520",
publisher = "Current Medicine Group",
number = "2",
}