Statins and Cognitive Function: an Updated Review

Saurav Chatterjee; Parasuram Krishnamoorthy; Pragya Ranjan; Ahana Roy; Anasua Chakraborty; Manpreet Singh Sabharwal; Richard Ro; Vikram Agarwal; Partha Sardar; Jacqueline Danik; Jay S. Giri; Emil M. DeGoma; Dharam J. Kumbhani

doi:10.1007/s11886-014-0559-3

Statins and Cognitive Function: an Updated Review

Saurav Chatterjee, Parasuram Krishnamoorthy, Pragya Ranjan, Ahana Roy, Anasua Chakraborty, Manpreet Singh Sabharwal, Richard Ro, Vikram Agarwal, Partha Sardar, Jacqueline Danik, Jay S. Giri, Emil M. DeGoma, Dharam J. Kumbhani

Research output: Contribution to journal › Review article › peer-review

21 Scopus citations

Abstract

Ischemic heart disease remains the leading cause of death in the USA. Statins have substantially contributed to the decline in mortality due to heart disease. Historically, statins are hypothesized to be neuroprotective and beneficial in dementia, but recent reports have suggested an association with transient cognitive decline. We have critically appraised the relationship between statins and cognitive function in this review. Most of the data are observational and reported a protective effect of statins on dementia and Alzheimer’s disease in patients with normal cognition at baseline. Few studies, including two randomized control trials, were unable to find a statistically significant decrease in the risk or improvement in patients with established dementia or decline in cognitive function with statin use. As more randomized control trials are required to definitively settle this, cardiovascular benefits of statins must be weighed against the risks of cognitive decline on an individual basis.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Current Cardiology Reports
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/s11886-014-0559-3
State	Published - Feb 2015

Keywords

Alzheimer’s disease
Cognitive function
Dementia
Statin use

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1007/s11886-014-0559-3

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title = "Statins and Cognitive Function: an Updated Review",

abstract = "Ischemic heart disease remains the leading cause of death in the USA. Statins have substantially contributed to the decline in mortality due to heart disease. Historically, statins are hypothesized to be neuroprotective and beneficial in dementia, but recent reports have suggested an association with transient cognitive decline. We have critically appraised the relationship between statins and cognitive function in this review. Most of the data are observational and reported a protective effect of statins on dementia and Alzheimer{\textquoteright}s disease in patients with normal cognition at baseline. Few studies, including two randomized control trials, were unable to find a statistically significant decrease in the risk or improvement in patients with established dementia or decline in cognitive function with statin use. As more randomized control trials are required to definitively settle this, cardiovascular benefits of statins must be weighed against the risks of cognitive decline on an individual basis.",

keywords = "Alzheimer{\textquoteright}s disease, Cognitive function, Dementia, Statin use",

author = "Saurav Chatterjee and Parasuram Krishnamoorthy and Pragya Ranjan and Ahana Roy and Anasua Chakraborty and Sabharwal, {Manpreet Singh} and Richard Ro and Vikram Agarwal and Partha Sardar and Jacqueline Danik and Giri, {Jay S.} and DeGoma, {Emil M.} and Kumbhani, {Dharam J.}",

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doi = "10.1007/s11886-014-0559-3",

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AU - Ranjan, Pragya

AU - Roy, Ahana

AU - Chakraborty, Anasua

AU - Sabharwal, Manpreet Singh

AU - Ro, Richard

AU - Agarwal, Vikram

AU - Sardar, Partha

AU - Danik, Jacqueline

AU - Giri, Jay S.

AU - DeGoma, Emil M.

AU - Kumbhani, Dharam J.

PY - 2015/2

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N2 - Ischemic heart disease remains the leading cause of death in the USA. Statins have substantially contributed to the decline in mortality due to heart disease. Historically, statins are hypothesized to be neuroprotective and beneficial in dementia, but recent reports have suggested an association with transient cognitive decline. We have critically appraised the relationship between statins and cognitive function in this review. Most of the data are observational and reported a protective effect of statins on dementia and Alzheimer’s disease in patients with normal cognition at baseline. Few studies, including two randomized control trials, were unable to find a statistically significant decrease in the risk or improvement in patients with established dementia or decline in cognitive function with statin use. As more randomized control trials are required to definitively settle this, cardiovascular benefits of statins must be weighed against the risks of cognitive decline on an individual basis.

AB - Ischemic heart disease remains the leading cause of death in the USA. Statins have substantially contributed to the decline in mortality due to heart disease. Historically, statins are hypothesized to be neuroprotective and beneficial in dementia, but recent reports have suggested an association with transient cognitive decline. We have critically appraised the relationship between statins and cognitive function in this review. Most of the data are observational and reported a protective effect of statins on dementia and Alzheimer’s disease in patients with normal cognition at baseline. Few studies, including two randomized control trials, were unable to find a statistically significant decrease in the risk or improvement in patients with established dementia or decline in cognitive function with statin use. As more randomized control trials are required to definitively settle this, cardiovascular benefits of statins must be weighed against the risks of cognitive decline on an individual basis.

KW - Alzheimer’s disease

KW - Cognitive function

KW - Dementia

KW - Statin use

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Statins and Cognitive Function: an Updated Review

Abstract

Keywords

ASJC Scopus subject areas

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