Statistical 3D prostate imaging atlas construction via anatomically constrained registration

Mirabela Rusu, B. Nicolas Bloch, Carl C. Jaffe, Neil M. Rofsky, Elizabeth M. Genega, Ernest Feleppa, Robert E. Lenkinski, Anant Madabhushi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Statistical imaging atlases allow for integration of information from multiple patient studies collected across different image scales and modalities, such as multi-parametric (MP) MRI and histology, providing population statistics regarding a specific pathology within a single canonical representation. Such atlases are particularly valuable in the identification and validation of meaningful imaging signatures for disease characterization in vivo within a population. Despite the high incidence of prostate cancer, an imaging atlas focused on different anatomic structures of the prostate, i.e. an anatomic atlas, has yet to be constructed. In this work we introduce a novel framework for MRI atlas construction that uses an iterative, anatomically constrained registration (AnCoR) scheme to enable the proper alignment of the prostate (Pr) and central gland (CG) boundaries. Our current implementation uses endorectal, 1.5T or 3T, T2-weighted MRI from 51 patients with biopsy confirmed cancer; however, the prostate atlas is seamlessly extensible to include additional MRI parameters. In our cohort, radical prostatectomy is performed following MP-MR image acquisition; thus ground truth annotations for prostate cancer are available from the histological specimens. Once mapped onto MP-MRI through elastic registration of histological slices to corresponding T2-w MRI slices, the annotations are utilized by the AnCoR framework to characterize the 3D statistical distribution of cancer per anatomic structure. Such distributions are useful for guiding biopsies toward regions of higher cancer likelihood and understanding imaging profiles for disease extent in vivo. We evaluate our approach via the Dice similarity coefficient (DSC) for different anatomic structures (delineated by expert radiologists): Pr, CG and peripheral zone (PZ). The AnCoR-based atlas had a CG DSC of 90.36%, and Pr DSC of 89.37%. Moreover, we evaluated the deviation of anatomic landmarks, the urethra and veromontanum, and found 3.64 mm and respectively 4.31 mm. Alternative strategies that use only the T2-w MRI or the prostate surface to drive the registration were implemented as comparative approaches. The AnCoR framework outperformed the alternative strategies by providing the lowest landmark deviations.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2013
Subtitle of host publicationImage Processing
DOIs
StatePublished - Jun 3 2013
EventMedical Imaging 2013: Image Processing - Lake Buena Vista, FL, United States
Duration: Feb 10 2013Feb 12 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8669
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2013: Image Processing
CountryUnited States
CityLake Buena Vista, FL
Period2/10/132/12/13

Keywords

  • 3D distribution
  • Anatomic atlas
  • Histology ground truth for cancer
  • Image guided biopsy
  • Imaging signature in vivo
  • Probabilistic atlas
  • Prostate
  • Prostate cancer

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Rusu, M., Bloch, B. N., Jaffe, C. C., Rofsky, N. M., Genega, E. M., Feleppa, E., Lenkinski, R. E., & Madabhushi, A. (2013). Statistical 3D prostate imaging atlas construction via anatomically constrained registration. In Medical Imaging 2013: Image Processing [866913] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8669). https://doi.org/10.1117/12.2006941