Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice

S. J. Estill; K. Fay; J. A. Garcia

doi:10.1023/A:1008955016170

Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice

S. J. Estill, K. Fay, J. A. Garcia

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.

Original language	English (US)
Pages (from-to)	157-175
Number of pages	19
Journal	Transgenic Research
Volume	10
Issue number	2
DOIs	https://doi.org/10.1023/A:1008955016170
State	Published - 2001

Keywords

129S6/SvEvTac
Behavior
C57BL/6J
Sample size
Test battery

ASJC Scopus subject areas

Biotechnology
Animal Science and Zoology
Genetics
Agronomy and Crop Science

Access to Document

10.1023/A:1008955016170

Cite this

@article{5706e312103749f3b114e24392f7cf07,

title = "Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice",

abstract = "Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.",

keywords = "129S6/SvEvTac, Behavior, C57BL/6J, Sample size, Test battery",

author = "Estill, {S. J.} and K. Fay and Garcia, {J. A.}",

year = "2001",

doi = "10.1023/A:1008955016170",

language = "English (US)",

volume = "10",

pages = "157--175",

journal = "Transgenic Research",

issn = "0962-8819",

publisher = "Springer Netherlands",

number = "2",

}

TY - JOUR

T1 - Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice

AU - Estill, S. J.

AU - Fay, K.

AU - Garcia, J. A.

PY - 2001

Y1 - 2001

N2 - Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.

AB - Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.

KW - 129S6/SvEvTac

KW - Behavior

KW - C57BL/6J

KW - Sample size

KW - Test battery

UR - http://www.scopus.com/inward/record.url?scp=0035086216&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035086216&partnerID=8YFLogxK

U2 - 10.1023/A:1008955016170

DO - 10.1023/A:1008955016170

M3 - Article

C2 - 11305362

AN - SCOPUS:0035086216

SN - 0962-8819

VL - 10

SP - 157

EP - 175

JO - Transgenic Research

JF - Transgenic Research

IS - 2

ER -

Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this