Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice

S. J. Estill, K. Fay, J. A. Garcia

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.

Original languageEnglish (US)
Pages (from-to)157-175
Number of pages19
JournalTransgenic Research
Volume10
Issue number2
DOIs
StatePublished - Apr 5 2001

Keywords

  • 129S6/SvEvTac
  • Behavior
  • C57BL/6J
  • Sample size
  • Test battery

ASJC Scopus subject areas

  • Biotechnology
  • Animal Science and Zoology
  • Agronomy and Crop Science
  • Genetics

Fingerprint Dive into the research topics of 'Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice'. Together they form a unique fingerprint.

Cite this