Stem cell niches for skin regeneration

Victor W. Wong, Benjamin Levi, Jayakumar Rajadas, Michael T. Longaker, Geoffrey C. Gurtner

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations

Abstract

Stem cell-based therapies offer tremendous potential for skin regeneration following injury and disease. Functional stem cell units have been described throughout all layers of human skin and the collective physical and chemical microenvironmental cues that enable this regenerative potential are known as the stem cell niche. Stem cells in the hair follicle bulge, interfollicular epidermis, dermal papillae, and perivascular space have been closely investigated as model systems for niche-driven regeneration. These studies suggest that stem cell strategies for skin engineering must consider the intricate molecular and biologic features of these niches. Innovative biomaterial systems that successfully recapitulate these microenvironments will facilitate progenitor cell-mediated skin repair and regeneration.

Original languageEnglish (US)
Article number926059
JournalInternational Journal of Biomaterials
DOIs
StatePublished - 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

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