Stem cells and brain cancer

Sara G M Piccirillo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cancer stem cells have been identified in human tumors. Initial findings in human leukemia suggested that tumors are organized hierarchically with a tumor-initiating rare cell population on the top of the hierarchy being responsible for tumor growth and metastasis. In the last decade, these findings have been extended to several human cancers, and although several convincing results have been published, it is still controversial if cancer stem cells represent a rare, immutable subpopulation perpetuating in the tumor or rather a functional state that many tumor cells can acquire. Since the term cancer stem cells seems to imply that tumor cells derive from normal stem cells of the same tissue, the definition as tumor - initiating cells found a better consensus. The ability of being tumor - initiating cells is the most important feature of these cells, and this is evaluated by the formation of phenocopies of the original tumor in animal models.

Original languageEnglish (US)
Title of host publicationEmerging Concepts in Neuro-Oncology
PublisherSpringer-Verlag London Ltd
Pages61-71
Number of pages11
Volume9780857294586
ISBN (Electronic)9780857294586
ISBN (Print)0857294571, 9780857294579
DOIs
StatePublished - Dec 1 2013

Fingerprint

Brain Neoplasms
Neoplastic Stem Cells
Stem Cells
Neoplasms
Leukemia
Animal Models
Neoplasm Metastasis
Growth
Population

Keywords

  • Brain -cancers
  • Cancer stem cells
  • Central nervous system
  • Glioblastoma
  • Tumorigenicity

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Piccirillo, S. G. M. (2013). Stem cells and brain cancer. In Emerging Concepts in Neuro-Oncology (Vol. 9780857294586, pp. 61-71). Springer-Verlag London Ltd. https://doi.org/10.1007/978-0-85729-458-6_4

Stem cells and brain cancer. / Piccirillo, Sara G M.

Emerging Concepts in Neuro-Oncology. Vol. 9780857294586 Springer-Verlag London Ltd, 2013. p. 61-71.

Research output: Chapter in Book/Report/Conference proceedingChapter

Piccirillo, SGM 2013, Stem cells and brain cancer. in Emerging Concepts in Neuro-Oncology. vol. 9780857294586, Springer-Verlag London Ltd, pp. 61-71. https://doi.org/10.1007/978-0-85729-458-6_4
Piccirillo SGM. Stem cells and brain cancer. In Emerging Concepts in Neuro-Oncology. Vol. 9780857294586. Springer-Verlag London Ltd. 2013. p. 61-71 https://doi.org/10.1007/978-0-85729-458-6_4
Piccirillo, Sara G M. / Stem cells and brain cancer. Emerging Concepts in Neuro-Oncology. Vol. 9780857294586 Springer-Verlag London Ltd, 2013. pp. 61-71
@inbook{6a9c4b84538e47d9a8260cd5214b55eb,
title = "Stem cells and brain cancer",
abstract = "Cancer stem cells have been identified in human tumors. Initial findings in human leukemia suggested that tumors are organized hierarchically with a tumor-initiating rare cell population on the top of the hierarchy being responsible for tumor growth and metastasis. In the last decade, these findings have been extended to several human cancers, and although several convincing results have been published, it is still controversial if cancer stem cells represent a rare, immutable subpopulation perpetuating in the tumor or rather a functional state that many tumor cells can acquire. Since the term cancer stem cells seems to imply that tumor cells derive from normal stem cells of the same tissue, the definition as tumor - initiating cells found a better consensus. The ability of being tumor - initiating cells is the most important feature of these cells, and this is evaluated by the formation of phenocopies of the original tumor in animal models.",
keywords = "Brain -cancers, Cancer stem cells, Central nervous system, Glioblastoma, Tumorigenicity",
author = "Piccirillo, {Sara G M}",
year = "2013",
month = "12",
day = "1",
doi = "10.1007/978-0-85729-458-6_4",
language = "English (US)",
isbn = "0857294571",
volume = "9780857294586",
pages = "61--71",
booktitle = "Emerging Concepts in Neuro-Oncology",
publisher = "Springer-Verlag London Ltd",

}

TY - CHAP

T1 - Stem cells and brain cancer

AU - Piccirillo, Sara G M

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Cancer stem cells have been identified in human tumors. Initial findings in human leukemia suggested that tumors are organized hierarchically with a tumor-initiating rare cell population on the top of the hierarchy being responsible for tumor growth and metastasis. In the last decade, these findings have been extended to several human cancers, and although several convincing results have been published, it is still controversial if cancer stem cells represent a rare, immutable subpopulation perpetuating in the tumor or rather a functional state that many tumor cells can acquire. Since the term cancer stem cells seems to imply that tumor cells derive from normal stem cells of the same tissue, the definition as tumor - initiating cells found a better consensus. The ability of being tumor - initiating cells is the most important feature of these cells, and this is evaluated by the formation of phenocopies of the original tumor in animal models.

AB - Cancer stem cells have been identified in human tumors. Initial findings in human leukemia suggested that tumors are organized hierarchically with a tumor-initiating rare cell population on the top of the hierarchy being responsible for tumor growth and metastasis. In the last decade, these findings have been extended to several human cancers, and although several convincing results have been published, it is still controversial if cancer stem cells represent a rare, immutable subpopulation perpetuating in the tumor or rather a functional state that many tumor cells can acquire. Since the term cancer stem cells seems to imply that tumor cells derive from normal stem cells of the same tissue, the definition as tumor - initiating cells found a better consensus. The ability of being tumor - initiating cells is the most important feature of these cells, and this is evaluated by the formation of phenocopies of the original tumor in animal models.

KW - Brain -cancers

KW - Cancer stem cells

KW - Central nervous system

KW - Glioblastoma

KW - Tumorigenicity

UR - http://www.scopus.com/inward/record.url?scp=84949177859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949177859&partnerID=8YFLogxK

U2 - 10.1007/978-0-85729-458-6_4

DO - 10.1007/978-0-85729-458-6_4

M3 - Chapter

AN - SCOPUS:84949177859

SN - 0857294571

SN - 9780857294579

VL - 9780857294586

SP - 61

EP - 71

BT - Emerging Concepts in Neuro-Oncology

PB - Springer-Verlag London Ltd

ER -