Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

Sean J. Morrison, Allan C. Spradling

Research output: Contribution to journalReview articlepeer-review

1278 Scopus citations

Abstract

Niches are local tissue microenvironments that maintain and regulate stem cells. Long-predicted from mammalian studies, these structures have recently been characterized within several invertebrate tissues using methods that reliably identify individual stem cells and their functional requirements. Although similar single-cell resolution has usually not been achieved in mammalian tissues, principles likely to govern the behavior of niches in diverse organisms are emerging. Considerable progress has been made in elucidating how the microenvironment promotes stem cell maintenance. Mechanisms of stem cell maintenance are key to the regulation of homeostasis and likely contribute to aging and tumorigenesis when altered during adulthood.

Original languageEnglish (US)
Pages (from-to)598-611
Number of pages14
JournalCell
Volume132
Issue number4
DOIs
StatePublished - Feb 22 2008

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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