Stem Cells in Brain Tumor Development

Sheila R. Alcantara Llaguno, Yuntao Chen, Renée M. McKay, Luis F. Parada

Research output: Book/ReportBook

10 Scopus citations

Abstract

Gliomas are highly infiltrative and aggressive brain tumors that are resistant to conventional therapies. Recent studies have implicated neural stem cells (NSCs) in brain tumor initiation and development. Subpopulations of stem-like cancer cells have also been isolated from brain tumors, and are purported to be important mediators of malignant behavior and therapeutic resistance. Similar signaling pathways may be operative in both neural and cancer stem cells, suggesting that neural developmental systems may provide important clues on brain tumorigenesis. Transcriptional regulators such as microRNAs may also contribute to NSC and brain tumor development. Understanding the biology of neural and cancer stem cells and their regulatory mechanisms may directly impact current efforts for more directed therapeutics against these highly aggressive tumors.

Original languageEnglish (US)
PublisherUnknown Publisher
Number of pages30
Volume94
EditionC
DOIs
StatePublished - 2011

Publication series

NameCurrent Topics in Developmental Biology
No.C
Volume94
ISSN (Print)00702153

Keywords

  • Cancer stem cells
  • Developmental pathways
  • GBM
  • Glioblastoma
  • Glioma
  • MicroRNA
  • Neural stem cells

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology

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  • Cite this

    Alcantara Llaguno, S. R., Chen, Y., McKay, R. M., & Parada, L. F. (2011). Stem Cells in Brain Tumor Development. (C ed.) (Current Topics in Developmental Biology; Vol. 94, No. C). Unknown Publisher. https://doi.org/10.1016/B978-0-12-380916-2.00002-4