@article{e916bf2cb5324b04939f7c1ce7e3f005,
title = "Stereocontrolled Formation of a [4.4]Heterospiro Ring System with Unexpected Inversion of Configuration at the Spirocenter",
abstract = "Stereoselective construction of the 1,3-diazaspiro[4.4]nonane core skeleton of massadine and related dimeric pyrrole-imidazole alkaloids is a synthetic challenge. We describe herein the synthesis of all C13/14 diastereomers of this spiro molecule through controlled oxidation and epimerization of the C13 spirocenter under mild acidic conditions.",
author = "Zhiqiang Ma and Lin You and Chuo Chen",
note = "Funding Information: We thank Dr. Vincent Lynch (University of Texas at Austin) for X-ray analysis of 13s. Financial support was provided by the NIH (NIGMS R01-GM079554), the Welch Foundation (I-1868), and UT Southwestern. Publisher Copyright: {\textcopyright} 2016 American Chemical Society. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2017",
month = jan,
day = "6",
doi = "10.1021/acs.joc.6b02266",
language = "English (US)",
volume = "82",
pages = "731--736",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "1",
}