Estudo estereológico das células de Purkinje cerebelares submetidas à intoxicação alcoólica em ratos Wistar

Translated title of the contribution: Stereologic study of the cerebellar Purkinje cells submitted to alcoholic intoxication in Wistar rats

Mara Ibis Rodrigues Apfel, Charles Alfred Ésberard, Fabrício Kafury Pereira Rodrigues, Fayez Mohamad Bahamad, Rafael Oliveira Sillero

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Background: to analyze the effect of the alcohol on the cells of Purkinje. Method: Wistar rats received alcoholic solutions orally in different concentrations 4%, 12% and 24%. The animals were sacrificed with 4, 8 and 12 weeks and the cerebella were randomly cut and embedded in paraffin. Sections of 6μm (H&E) were stereologically analyzed. Results: The differences among the density for area and density of surface of the cells of Purkinje of all of the experimental groups (E) and the respective controls (C) were significant. With 12 weeks the cell of Purkinje volume density decreased among the groups C and E in the concentrations of 4% and 12%, but not for the concentration of 24%, probably due to smaller liquid ingestion by the animals. Conclusion: The alcohol has toxic effect on the Purkinje cellular body in the three studied concentrations from 4 weeks.

Translated title of the contributionStereologic study of the cerebellar Purkinje cells submitted to alcoholic intoxication in Wistar rats
Original languagePortuguese
Pages (from-to)258-263
Number of pages6
JournalArquivos de Neuro-Psiquiatria
Volume60
Issue number2 A
DOIs
StatePublished - Jun 2002

Keywords

  • Alcohol
  • Cerebellum
  • Purkinje cell
  • Stereology

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Stereologic study of the cerebellar Purkinje cells submitted to alcoholic intoxication in Wistar rats'. Together they form a unique fingerprint.

  • Cite this