Stereoselectivity of l-baclofen in hippocampal slices of the rat

H. L. Haas, R. W. Greene, H. R. Olpe

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Extra- and intracellular recording from hippocampal slices of the rat revealed the following effects when baclofen (BF) (0.1-10 μM) was added to the perfusion fluid: a block of synaptic potentials evoked by stimulation of stratum radiatum; a direct hyperpolarization and a conductance increase (for potassium ions) of CA1 pyramidal cells. All this activity was found in the l- and none in the d- enantiomer. d-BF did not antagonize the action of l-BF.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Volume55
Issue number1
DOIs
StatePublished - Mar 22 1985

Keywords

  • baclofen
  • hippocampal slice
  • rat
  • stereoselectivity

ASJC Scopus subject areas

  • Neuroscience(all)

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