Stereoselectivity of l-baclofen in hippocampal slices of the rat

H. L. Haas, R. W. Greene, H. R. Olpe

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Extra- and intracellular recording from hippocampal slices of the rat revealed the following effects when baclofen (BF) (0.1-10 μM) was added to the perfusion fluid: a block of synaptic potentials evoked by stimulation of stratum radiatum; a direct hyperpolarization and a conductance increase (for potassium ions) of CA1 pyramidal cells. All this activity was found in the l- and none in the d- enantiomer. d-BF did not antagonize the action of l-BF.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Volume55
Issue number1
DOIs
StatePublished - Mar 22 1985

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Baclofen
Synaptic Potentials
Pyramidal Cells
Potassium
Perfusion
Ions

Keywords

  • baclofen
  • hippocampal slice
  • rat
  • stereoselectivity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Stereoselectivity of l-baclofen in hippocampal slices of the rat. / Haas, H. L.; Greene, R. W.; Olpe, H. R.

In: Neuroscience Letters, Vol. 55, No. 1, 22.03.1985, p. 1-4.

Research output: Contribution to journalArticle

Haas, H. L. ; Greene, R. W. ; Olpe, H. R. / Stereoselectivity of l-baclofen in hippocampal slices of the rat. In: Neuroscience Letters. 1985 ; Vol. 55, No. 1. pp. 1-4.
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