Stereospecific α-alkoxystannane couplings with acyl chlorides: Total synthesis of (+)-goniofufurone

Jianhua Ye, Rama K. Bhatt, J. R. Falck

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Stereospecific C-glycoside formation via Pd/Cu mediated coupling of PhCOCl with cyclic α-alkoxystannane 6, derived from D-glucurono-6,3-lactone, was the key transformation in a concise total synthesis of the anticancer agent (+)-goniofufurone.

Original languageEnglish (US)
Pages (from-to)8007-8010
Number of pages4
JournalTetrahedron Letters
Volume34
Issue number50
DOIs
StatePublished - Dec 10 1993

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Lactones
Antineoplastic Agents
Chlorides
C-glycoside
7-goniofufurone

Keywords

  • anticancer
  • C-glycoside
  • palladium
  • Stille coupling
  • tin.

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Stereospecific α-alkoxystannane couplings with acyl chlorides : Total synthesis of (+)-goniofufurone. / Ye, Jianhua; Bhatt, Rama K.; Falck, J. R.

In: Tetrahedron Letters, Vol. 34, No. 50, 10.12.1993, p. 8007-8010.

Research output: Contribution to journalArticle

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