Stereospecific Stille Cross-Couplings Using Mn(II)Cl2

Rambabu Dakarapu, J R Falck

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Cross-coupling reactions are a staple in organic synthesis, especially for C-C bond formation with sp- and sp2-carbon electrophiles. In recent years, the range of accessible C-C bonds has been extended to stereogenic centers which expedites access to greater molecular complexity. However, these reactions predominantly depend upon late transition metal (LTM) catalysts whose cost, toxicity, and/or environmental impact have come under increasing scrutiny and governmental regulation. Here, we report Mn(II)Cl2 complexes alone, or with assistance from copper, catalyze the stereospecific cross-coupling of α-alkoxyalkylstannanes with organic electrophiles with complete retention of configuration.

Original languageEnglish (US)
Pages (from-to)1241-1251
Number of pages11
JournalJournal of Organic Chemistry
Volume83
Issue number3
DOIs
StatePublished - Feb 2 2018

ASJC Scopus subject areas

  • Organic Chemistry

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