Stereospecific suzuki cross-coupling of alkyl α-cyanohydrin triflates

Anyu He, J. R. Falck

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

(Figure Presented) Scalemic α-cyanohydrin triflates undergo Pd-catalyzed cross-coupling with aryl, heteroaryl, and vinyl boronic acids under mild conditions. Coupling proceeds with complete inversion of configuration at the stereogenic carbon. The resultant nitrile can be easily converted into a variety of alternative functional groups of value in organic synthesis and thus achieves a higher level of molecular complexity than the products of traditional Suzuki reactions.

Original languageEnglish (US)
Pages (from-to)2524-2525
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number8
DOIs
StatePublished - Feb 24 2010

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Boronic Acids
Synthetic Chemistry Techniques
Nitriles
Functional groups
Carbon
Acids
cyanohydrin

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Stereospecific suzuki cross-coupling of alkyl α-cyanohydrin triflates. / He, Anyu; Falck, J. R.

In: Journal of the American Chemical Society, Vol. 132, No. 8, 24.02.2010, p. 2524-2525.

Research output: Contribution to journalArticle

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