Stereospecific suzuki cross-coupling of alkyl α-cyanohydrin triflates

Anyu He, J. R. Falck

Research output: Contribution to journalArticle

85 Scopus citations

Abstract

(Figure Presented) Scalemic α-cyanohydrin triflates undergo Pd-catalyzed cross-coupling with aryl, heteroaryl, and vinyl boronic acids under mild conditions. Coupling proceeds with complete inversion of configuration at the stereogenic carbon. The resultant nitrile can be easily converted into a variety of alternative functional groups of value in organic synthesis and thus achieves a higher level of molecular complexity than the products of traditional Suzuki reactions.

Original languageEnglish (US)
Pages (from-to)2524-2525
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number8
DOIs
StatePublished - Feb 24 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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