Stereospecific synthesis of EET metabolites via Suzuki-Miyaura coupling

J. R. Falck, P. Srinagesh Kumar, Y. Krishna Reddy, Gang Zou, Jorge H. Capdevila

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Bioactive, chain-shortened EET metabolites, viz. 8,9-epoxytetradec-5(Z)-enoic acid and 9,10-epoxyoctadec-6(Z),12(Z)-dienoic acid, were prepared via Suzuki-Miyaura cross-couplings of n-alkylboronic acids with chiral vinyl iodides.

Original languageEnglish (US)
Pages (from-to)7211-7212
Number of pages2
JournalTetrahedron Letters
Volume42
Issue number41
DOIs
StatePublished - Oct 8 2001

Keywords

  • Biologically active compounds
  • Eicosanoids
  • Lipids
  • Silver
  • Suzuki-Miyaura

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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