Stereospecific synthesis of trans-arachidonic acids

U. Murali Krishna; M. Muralidhar Reddy; Jianing Xia; J. R. Falck; Michael Balazy

doi:10.1016/S0960-894X(01)00442-5

Stereospecific synthesis of trans-arachidonic acids

U. Murali Krishna, M. Muralidhar Reddy, Jianing Xia, J. R. Falck, Michael Balazy

Biochemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.

Original language	English (US)
Pages (from-to)	2415-2418
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(01)00442-5
State	Published - Sep 17 2001

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(01)00442-5

Cite this

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title = "Stereospecific synthesis of trans-arachidonic acids",

abstract = "An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.",

author = "Krishna, {U. Murali} and Reddy, {M. Muralidhar} and Jianing Xia and Falck, {J. R.} and Michael Balazy",

note = "Funding Information: This research was supported by grants GM31278 and GM62453 from the National Institutes of Health, the Robert A. Welch Foundation and the American Heart Association.",

year = "2001",

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T1 - Stereospecific synthesis of trans-arachidonic acids

AU - Krishna, U. Murali

AU - Reddy, M. Muralidhar

AU - Xia, Jianing

AU - Falck, J. R.

AU - Balazy, Michael

N1 - Funding Information: This research was supported by grants GM31278 and GM62453 from the National Institutes of Health, the Robert A. Welch Foundation and the American Heart Association.

PY - 2001/9/17

Y1 - 2001/9/17

N2 - An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.

AB - An effective synthesis is described for the preparation of all four mono trans isomers of arachidonic acid via deoxidation of epoxide precursors with lithium diphenylphosphide and quaternization with methyl iodide.

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U2 - 10.1016/S0960-894X(01)00442-5

DO - 10.1016/S0960-894X(01)00442-5

M3 - Article

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AN - SCOPUS:0035903841

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Stereospecific synthesis of trans-arachidonic acids

Abstract

ASJC Scopus subject areas

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