Stereotactic ablative body radiosurgery (SABR) or Stereotactic body radiation therapy (SBRT)

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

While conventional treatment relies on protracted courses of therapy using relatively small dose-per-fraction sizes of 1.8–2 Gy, there is substantial evidence gathered over decades that this may not be the optimal approach for all targetable disease. Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT) is a technique which uses precise targeting to deliver high doses of radiation capable of ablating tumors directly. In this review, we will discuss the justification for and techniques used to deliver ablative doses to improve treatment outcomes, interactions with biological and immunologic therapy, and special procedures to spare normal tissue, which have facilitated the expanding role for these techniques in the management of a wide range of malignant histologies and disease states.

Original languageEnglish (US)
Pages (from-to)3-14
Number of pages12
JournalAdvanced Drug Delivery Reviews
Volume109
DOIs
StatePublished - Jan 15 2017

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Radiosurgery
Radiotherapy
Biological Therapy
Histology
Radiation
Therapeutics
Neoplasms

Keywords

  • Ablative therapy
  • Abscopal effect
  • Conventional fractionation
  • Liver radiation, Prostate radiation
  • Lung radiation
  • Normal tissue toxicity
  • Oligometastases
  • SABR
  • SBRT
  • Spine radiation
  • Stereotactic radiation
  • Targeted therapy
  • Temporary organ displacement
  • Therapeutic ratio

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

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title = "Stereotactic ablative body radiosurgery (SABR) or Stereotactic body radiation therapy (SBRT)",
abstract = "While conventional treatment relies on protracted courses of therapy using relatively small dose-per-fraction sizes of 1.8–2 Gy, there is substantial evidence gathered over decades that this may not be the optimal approach for all targetable disease. Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT) is a technique which uses precise targeting to deliver high doses of radiation capable of ablating tumors directly. In this review, we will discuss the justification for and techniques used to deliver ablative doses to improve treatment outcomes, interactions with biological and immunologic therapy, and special procedures to spare normal tissue, which have facilitated the expanding role for these techniques in the management of a wide range of malignant histologies and disease states.",
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AU - Folkert, Michael R.

AU - Timmerman, Robert D.

PY - 2017/1/15

Y1 - 2017/1/15

N2 - While conventional treatment relies on protracted courses of therapy using relatively small dose-per-fraction sizes of 1.8–2 Gy, there is substantial evidence gathered over decades that this may not be the optimal approach for all targetable disease. Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT) is a technique which uses precise targeting to deliver high doses of radiation capable of ablating tumors directly. In this review, we will discuss the justification for and techniques used to deliver ablative doses to improve treatment outcomes, interactions with biological and immunologic therapy, and special procedures to spare normal tissue, which have facilitated the expanding role for these techniques in the management of a wide range of malignant histologies and disease states.

AB - While conventional treatment relies on protracted courses of therapy using relatively small dose-per-fraction sizes of 1.8–2 Gy, there is substantial evidence gathered over decades that this may not be the optimal approach for all targetable disease. Stereotactic ablative body radiosurgery (SABR) or stereotactic body radiation therapy (SBRT) is a technique which uses precise targeting to deliver high doses of radiation capable of ablating tumors directly. In this review, we will discuss the justification for and techniques used to deliver ablative doses to improve treatment outcomes, interactions with biological and immunologic therapy, and special procedures to spare normal tissue, which have facilitated the expanding role for these techniques in the management of a wide range of malignant histologies and disease states.

KW - Ablative therapy

KW - Abscopal effect

KW - Conventional fractionation

KW - Liver radiation, Prostate radiation

KW - Lung radiation

KW - Normal tissue toxicity

KW - Oligometastases

KW - SABR

KW - SBRT

KW - Spine radiation

KW - Stereotactic radiation

KW - Targeted therapy

KW - Temporary organ displacement

KW - Therapeutic ratio

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