Stereotactic body radiation therapy for renal cell carcinoma with inferior vena cava thrombus-initial experience report and literature review

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Renal cell carcinoma (RCC) with inferior vena cava thrombus (IVC-TT) represents a relatively infrequent presentation. Curative treatment includes extirpative surgery; however, this is associated with high rates of recurrence and complications. Stereotactic body radiation therapy (SBRT) has been used to treat metastatic RCC with good results. SBRT may be used as part of multimodal therapy to provide local control of IVC-TT. Objective: We report our initial experience with SBRT to IVC-TT, including extended follow-up, and review the literature. Results: We report on two patients with level IV IVC-TT. Both had progressive disease while receiving systemic therapy and were eventually treated with SBRT to the IVC-TT, which showed good local control. Overall survival from the time of SBRT was 18 and 34 months, with no additional systemic therapy; one patient underwent additional SBRT and resection of metastatic sites. Conclusions: SBRT to RCC IVC-TT may be considered in selected patients for local tumor control.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalKidney Cancer
Volume3
Issue number1
DOIs
StatePublished - 2019

Keywords

  • invasion
  • IVC
  • nephrectomy
  • RCC
  • SABR
  • SBRT
  • stage III renal cancer
  • tumor thrombus
  • UTSW
  • vascular migration

ASJC Scopus subject areas

  • Nephrology
  • Oncology

Fingerprint

Dive into the research topics of 'Stereotactic body radiation therapy for renal cell carcinoma with inferior vena cava thrombus-initial experience report and literature review'. Together they form a unique fingerprint.

Cite this