Abstract
Lymphocytic hypophysitis is a rare inflammatory disorder of the pituitary gland. Standard therapy consists of transsphenoidal resection or oral administration of corticosteroid medications. Two patients with symptomatic lymphocytic hypophysitis, which recurred after standard therapy, were treated with low-dose stereotactic radiotherapy. On imaging studies both lesions demonstrated a response to radiation and each patient experienced relief of symptoms. There has been no adverse sequela of the radiation treatment. The authors conclude that stereotactic radiotherapy represents an effective, noninvasive treatment option for patients with lymphocytic hypophysitis, particularly if the disease is recurrent after surgery or resistant to corticosteroid medications.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 591-596 |
| Number of pages | 6 |
| Journal | Journal of Neurosurgery |
| Volume | 99 |
| Issue number | 3 |
| State | Published - Sep 1 2003 |
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Keywords
- Lymphocytic hypophysitis
- Stereotactic radiotherapy
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases. / Selch, Michael T.; DeSalles, Antonio A F; Kelly, Daniel F.; Frighetto, Leonardo; Vinters, Harry V.; Cabatan-Awang, Cynthia; Wallace, Robert E.; Solberg, Timothy D.
In: Journal of Neurosurgery, Vol. 99, No. 3, 01.09.2003, p. 591-596.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases
AU - Selch, Michael T.
AU - DeSalles, Antonio A F
AU - Kelly, Daniel F.
AU - Frighetto, Leonardo
AU - Vinters, Harry V.
AU - Cabatan-Awang, Cynthia
AU - Wallace, Robert E.
AU - Solberg, Timothy D.
PY - 2003/9/1
Y1 - 2003/9/1
N2 - Lymphocytic hypophysitis is a rare inflammatory disorder of the pituitary gland. Standard therapy consists of transsphenoidal resection or oral administration of corticosteroid medications. Two patients with symptomatic lymphocytic hypophysitis, which recurred after standard therapy, were treated with low-dose stereotactic radiotherapy. On imaging studies both lesions demonstrated a response to radiation and each patient experienced relief of symptoms. There has been no adverse sequela of the radiation treatment. The authors conclude that stereotactic radiotherapy represents an effective, noninvasive treatment option for patients with lymphocytic hypophysitis, particularly if the disease is recurrent after surgery or resistant to corticosteroid medications.
AB - Lymphocytic hypophysitis is a rare inflammatory disorder of the pituitary gland. Standard therapy consists of transsphenoidal resection or oral administration of corticosteroid medications. Two patients with symptomatic lymphocytic hypophysitis, which recurred after standard therapy, were treated with low-dose stereotactic radiotherapy. On imaging studies both lesions demonstrated a response to radiation and each patient experienced relief of symptoms. There has been no adverse sequela of the radiation treatment. The authors conclude that stereotactic radiotherapy represents an effective, noninvasive treatment option for patients with lymphocytic hypophysitis, particularly if the disease is recurrent after surgery or resistant to corticosteroid medications.
KW - Lymphocytic hypophysitis
KW - Stereotactic radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=0041920809&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0041920809&partnerID=8YFLogxK
M3 - Article
C2 - 12959451
AN - SCOPUS:0041920809
VL - 99
SP - 591
EP - 596
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - 3
ER -