Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases

Michael T. Selch, Antonio A F DeSalles, Daniel F. Kelly, Leonardo Frighetto, Harry V. Vinters, Cynthia Cabatan-Awang, Robert E. Wallace, Timothy D. Solberg

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Lymphocytic hypophysitis is a rare inflammatory disorder of the pituitary gland. Standard therapy consists of transsphenoidal resection or oral administration of corticosteroid medications. Two patients with symptomatic lymphocytic hypophysitis, which recurred after standard therapy, were treated with low-dose stereotactic radiotherapy. On imaging studies both lesions demonstrated a response to radiation and each patient experienced relief of symptoms. There has been no adverse sequela of the radiation treatment. The authors conclude that stereotactic radiotherapy represents an effective, noninvasive treatment option for patients with lymphocytic hypophysitis, particularly if the disease is recurrent after surgery or resistant to corticosteroid medications.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalJournal of Neurosurgery
Volume99
Issue number3
StatePublished - Sep 1 2003

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Radiotherapy
Adrenal Cortex Hormones
Radiation
Pituitary Gland
Therapeutics
Oral Administration
Autoimmune Hypophysitis

Keywords

  • Lymphocytic hypophysitis
  • Stereotactic radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Selch, M. T., DeSalles, A. A. F., Kelly, D. F., Frighetto, L., Vinters, H. V., Cabatan-Awang, C., ... Solberg, T. D. (2003). Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases. Journal of Neurosurgery, 99(3), 591-596.

Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases. / Selch, Michael T.; DeSalles, Antonio A F; Kelly, Daniel F.; Frighetto, Leonardo; Vinters, Harry V.; Cabatan-Awang, Cynthia; Wallace, Robert E.; Solberg, Timothy D.

In: Journal of Neurosurgery, Vol. 99, No. 3, 01.09.2003, p. 591-596.

Research output: Contribution to journalArticle

Selch, MT, DeSalles, AAF, Kelly, DF, Frighetto, L, Vinters, HV, Cabatan-Awang, C, Wallace, RE & Solberg, TD 2003, 'Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases', Journal of Neurosurgery, vol. 99, no. 3, pp. 591-596.
Selch MT, DeSalles AAF, Kelly DF, Frighetto L, Vinters HV, Cabatan-Awang C et al. Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases. Journal of Neurosurgery. 2003 Sep 1;99(3):591-596.
Selch, Michael T. ; DeSalles, Antonio A F ; Kelly, Daniel F. ; Frighetto, Leonardo ; Vinters, Harry V. ; Cabatan-Awang, Cynthia ; Wallace, Robert E. ; Solberg, Timothy D. / Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases. In: Journal of Neurosurgery. 2003 ; Vol. 99, No. 3. pp. 591-596.
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