Steroid hormones are key modulators of tissue mechanical function via regulation of collagen and elastic fibers

Shanmugasundaram Nallasamy, Kyoko Yoshida, Meredith Akins, Kristin Myers, Renato Iozzo, Mala Mahendroo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The extracellular matrix (ECM) plays an active and dynamic role that both reflects and facilitates the functional requirements of a tissue. The mature ECM of the nonpregnant cervix is drastically reorganized during pregnancy to drive changes in tissue mechanics that ensure safe birth. In this study, our research on mice deficient in the proteoglycan decorin have led to the finding that progesterone and estrogen play distinct and complementary roles to orchestrate structural reorganization of both collagen and elastic fibers in the cervix during pregnancy. Abnormalities in collagen and elastic fiber structure and tissue mechanical function evident in the cervix of nonpregnant and early pregnant decorin-null mice transiently recover for the remainder of pregnancy only to return 1 month postpartum. Consistent with the hypothesis that pregnancy levels of progesterone and estrogen may regulate ECM organization and turnover, expressions of factors required for assembly and synthesis of collagen and elastic fibers are temporally regulated, and the ultrastructure of collagen fibrils and elastic fibers is markedly altered during pregnancy in wild-type mice. Finally, utilizing ovariectomized nonpregnant decorin-null mice, we demonstrate structural resolution of collagen and elastic fibers by progesterone or estrogen, respectively, and the potential for both ECM proteins to contribute to mechanical function. These investigations advance understanding of regulatory factors that drive specialized ECM organization and contribute to an understanding of the cervical remodeling process, which may provide insight into potential complications associated with preterm birth that impact 9.6% of live births in the United States.

Original languageEnglish (US)
Pages (from-to)950-962
Number of pages13
JournalEndocrinology
Volume158
Issue number4
DOIs
StatePublished - Apr 1 2017

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Elastic Tissue
Collagen
Steroids
Hormones
Decorin
Extracellular Matrix
Pregnancy
Cervix Uteri
Progesterone
Estrogens
Extracellular Matrix Proteins
Premature Birth
Live Birth
Proteoglycans
Mechanics
Postpartum Period
Parturition
Research

ASJC Scopus subject areas

  • Endocrinology

Cite this

Steroid hormones are key modulators of tissue mechanical function via regulation of collagen and elastic fibers. / Nallasamy, Shanmugasundaram; Yoshida, Kyoko; Akins, Meredith; Myers, Kristin; Iozzo, Renato; Mahendroo, Mala.

In: Endocrinology, Vol. 158, No. 4, 01.04.2017, p. 950-962.

Research output: Contribution to journalArticle

Nallasamy, Shanmugasundaram ; Yoshida, Kyoko ; Akins, Meredith ; Myers, Kristin ; Iozzo, Renato ; Mahendroo, Mala. / Steroid hormones are key modulators of tissue mechanical function via regulation of collagen and elastic fibers. In: Endocrinology. 2017 ; Vol. 158, No. 4. pp. 950-962.
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