Sterol regulatory element-binding proteins: Transcriptional activators of lipid synthesis

Research output: Contribution to journalArticle

239 Citations (Scopus)

Abstract

Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activation properties of each SREBP isoform facilitates the co-ordinate regulation of all essential lipid building blocks required for cell membranes as well as for very-low-density lipoprotein formation in hepatocytes.

Original languageEnglish (US)
Pages (from-to)1091-1095
Number of pages5
JournalBiochemical Society Transactions
Volume30
Issue number6
DOIs
StatePublished - Nov 2002

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Sterol Regulatory Element Binding Proteins
Lipids
Protein Isoforms
VLDL Lipoproteins
Biosynthesis
Cell membranes
Hepatocytes
Phospholipids
Triglycerides
Homeostasis
Transcription Factors
Fatty Acids
Genes
Chemical activation
Cholesterol
Cell Membrane

Keywords

  • Cholesterol
  • Fatty acids
  • Lipogenesis
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry

Cite this

Sterol regulatory element-binding proteins : Transcriptional activators of lipid synthesis. / Horton, Jay D.

In: Biochemical Society Transactions, Vol. 30, No. 6, 11.2002, p. 1091-1095.

Research output: Contribution to journalArticle

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