STIM1 moonlights as an anchor for STING

Jianjun Wu, Nan Yan

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Activation of STING requires its translocation from the endoplasmic reticulum (ER) through the Golgi to vesicles, but the mechanisms that control its localization have been unclear. The ER calcium sensor STIM1 acts as an ER-retention factor that anchors STING on the ER and limits STING signaling.

Original languageEnglish (US)
Pages (from-to)112-114
Number of pages3
JournalNature Immunology
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2019

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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