Stimulated growth hormone concentrations in obese pediatric patients with mild and severe insulin resistance

A pilot study

Jill A. Radack, Perrin C. White, Beverley Adams-Huet, Jon D. Oden

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: GH excess predisposes to insulin resistance (IR). Obese patients have blunted responses to GH stimulation and decreased spontaneous secretion. GH secretion has not been studied in the context of IR. Objective: To determine whether varying degrees of IR effects GH dynamics in obese children. Patients/Design: Patients (all > 10 y) were categorized according to gender and HOMA-IR to have either mild or severe IR. Twenty patients (10 female) with mild IR completed the study, as did 18 (9 female) in the severe group. Each patient underwent a GH stimulation test with GHRH. GH peak and area under the curve (AUC) were compared between the groups. Results: Severe IR females had higher peak GH (mean±SD, 9.5±4.4 vs. 5.8±3.7 ng/dl, p=0.04) and trended toward higher GH AUC (356±207 vs. 221±128, p=0.06) than mild IR females. There were no differences in GH response in males, Conclusions: There may be a positive relationship between severity of IR and peak GH in obese girls.

Original languageEnglish (US)
Pages (from-to)355-361
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume23
Issue number4
StatePublished - Apr 2010

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Growth Hormone
Insulin Resistance
Pediatrics
Area Under Curve

Keywords

  • Acid labile subunit
  • Growth hormone
  • Homeostasis model assessment index of insulin resistance
  • Insulin resistance
  • Obesity

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Stimulated growth hormone concentrations in obese pediatric patients with mild and severe insulin resistance: A pilot study",
abstract = "Background: GH excess predisposes to insulin resistance (IR). Obese patients have blunted responses to GH stimulation and decreased spontaneous secretion. GH secretion has not been studied in the context of IR. Objective: To determine whether varying degrees of IR effects GH dynamics in obese children. Patients/Design: Patients (all > 10 y) were categorized according to gender and HOMA-IR to have either mild or severe IR. Twenty patients (10 female) with mild IR completed the study, as did 18 (9 female) in the severe group. Each patient underwent a GH stimulation test with GHRH. GH peak and area under the curve (AUC) were compared between the groups. Results: Severe IR females had higher peak GH (mean±SD, 9.5±4.4 vs. 5.8±3.7 ng/dl, p=0.04) and trended toward higher GH AUC (356±207 vs. 221±128, p=0.06) than mild IR females. There were no differences in GH response in males, Conclusions: There may be a positive relationship between severity of IR and peak GH in obese girls.",
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AU - Radack, Jill A.

AU - White, Perrin C.

AU - Adams-Huet, Beverley

AU - Oden, Jon D.

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N2 - Background: GH excess predisposes to insulin resistance (IR). Obese patients have blunted responses to GH stimulation and decreased spontaneous secretion. GH secretion has not been studied in the context of IR. Objective: To determine whether varying degrees of IR effects GH dynamics in obese children. Patients/Design: Patients (all > 10 y) were categorized according to gender and HOMA-IR to have either mild or severe IR. Twenty patients (10 female) with mild IR completed the study, as did 18 (9 female) in the severe group. Each patient underwent a GH stimulation test with GHRH. GH peak and area under the curve (AUC) were compared between the groups. Results: Severe IR females had higher peak GH (mean±SD, 9.5±4.4 vs. 5.8±3.7 ng/dl, p=0.04) and trended toward higher GH AUC (356±207 vs. 221±128, p=0.06) than mild IR females. There were no differences in GH response in males, Conclusions: There may be a positive relationship between severity of IR and peak GH in obese girls.

AB - Background: GH excess predisposes to insulin resistance (IR). Obese patients have blunted responses to GH stimulation and decreased spontaneous secretion. GH secretion has not been studied in the context of IR. Objective: To determine whether varying degrees of IR effects GH dynamics in obese children. Patients/Design: Patients (all > 10 y) were categorized according to gender and HOMA-IR to have either mild or severe IR. Twenty patients (10 female) with mild IR completed the study, as did 18 (9 female) in the severe group. Each patient underwent a GH stimulation test with GHRH. GH peak and area under the curve (AUC) were compared between the groups. Results: Severe IR females had higher peak GH (mean±SD, 9.5±4.4 vs. 5.8±3.7 ng/dl, p=0.04) and trended toward higher GH AUC (356±207 vs. 221±128, p=0.06) than mild IR females. There were no differences in GH response in males, Conclusions: There may be a positive relationship between severity of IR and peak GH in obese girls.

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