Stimulating somatic afferent fibers alters coronary arterial resistance

K. H. Pitetti, G. A. Iwamoto, J. H. Mitchell, G. A. Ordway

Research output: Contribution to journalArticle

Abstract

We used a constant flow preparation to study the changes in left circumflex coronary arterial (LCCA) pressure and resistance evoked by electrical stimulation of branches of muscle, cutaneous, and mixed nerves in the hindlimb of anesthetized dogs. Stimulation (20 Hz) of all three nerve types at 20, 70, 100, and 200 times the voltage threshold that evoked compound action potentials significantly (P<0.05) increased LCCA resistance. Stimulation at three and five times threshold had no effect on this same variable. Cooling the nerve to 2-4°C, temperature that block myelinated nerve fibers, attenuated but did not abolish the increase in LCCA resistance. Combinations of β- and α-adrenergic and cholinergic blockade established that the biphasic change evoked by nerve stimulation was due to an initial α-adrenergic vasoconstriction followed by a metabolite-induced vasodilation. These data demonstrate that stimulation of muscle, cutaneous, or mixed nerve afferent C-fibers increases coronary arterial resistance by α-adrenergic vasoconstriction.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume256
Issue number6
StatePublished - 1989

Fingerprint

Adrenergic Agents
Vasoconstriction
Myelinated Nerve Fibers
Muscles
Unmyelinated Nerve Fibers
Skin
Hindlimb
Vasodilation
Cholinergic Agents
Electric Stimulation
Action Potentials
Arterial Pressure
Dogs
Temperature

ASJC Scopus subject areas

  • Physiology

Cite this

@article{dd09a30325364a1e8bd58874deb481fe,
title = "Stimulating somatic afferent fibers alters coronary arterial resistance",
abstract = "We used a constant flow preparation to study the changes in left circumflex coronary arterial (LCCA) pressure and resistance evoked by electrical stimulation of branches of muscle, cutaneous, and mixed nerves in the hindlimb of anesthetized dogs. Stimulation (20 Hz) of all three nerve types at 20, 70, 100, and 200 times the voltage threshold that evoked compound action potentials significantly (P<0.05) increased LCCA resistance. Stimulation at three and five times threshold had no effect on this same variable. Cooling the nerve to 2-4°C, temperature that block myelinated nerve fibers, attenuated but did not abolish the increase in LCCA resistance. Combinations of β- and α-adrenergic and cholinergic blockade established that the biphasic change evoked by nerve stimulation was due to an initial α-adrenergic vasoconstriction followed by a metabolite-induced vasodilation. These data demonstrate that stimulation of muscle, cutaneous, or mixed nerve afferent C-fibers increases coronary arterial resistance by α-adrenergic vasoconstriction.",
author = "Pitetti, {K. H.} and Iwamoto, {G. A.} and Mitchell, {J. H.} and Ordway, {G. A.}",
year = "1989",
language = "English (US)",
volume = "256",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Stimulating somatic afferent fibers alters coronary arterial resistance

AU - Pitetti, K. H.

AU - Iwamoto, G. A.

AU - Mitchell, J. H.

AU - Ordway, G. A.

PY - 1989

Y1 - 1989

N2 - We used a constant flow preparation to study the changes in left circumflex coronary arterial (LCCA) pressure and resistance evoked by electrical stimulation of branches of muscle, cutaneous, and mixed nerves in the hindlimb of anesthetized dogs. Stimulation (20 Hz) of all three nerve types at 20, 70, 100, and 200 times the voltage threshold that evoked compound action potentials significantly (P<0.05) increased LCCA resistance. Stimulation at three and five times threshold had no effect on this same variable. Cooling the nerve to 2-4°C, temperature that block myelinated nerve fibers, attenuated but did not abolish the increase in LCCA resistance. Combinations of β- and α-adrenergic and cholinergic blockade established that the biphasic change evoked by nerve stimulation was due to an initial α-adrenergic vasoconstriction followed by a metabolite-induced vasodilation. These data demonstrate that stimulation of muscle, cutaneous, or mixed nerve afferent C-fibers increases coronary arterial resistance by α-adrenergic vasoconstriction.

AB - We used a constant flow preparation to study the changes in left circumflex coronary arterial (LCCA) pressure and resistance evoked by electrical stimulation of branches of muscle, cutaneous, and mixed nerves in the hindlimb of anesthetized dogs. Stimulation (20 Hz) of all three nerve types at 20, 70, 100, and 200 times the voltage threshold that evoked compound action potentials significantly (P<0.05) increased LCCA resistance. Stimulation at three and five times threshold had no effect on this same variable. Cooling the nerve to 2-4°C, temperature that block myelinated nerve fibers, attenuated but did not abolish the increase in LCCA resistance. Combinations of β- and α-adrenergic and cholinergic blockade established that the biphasic change evoked by nerve stimulation was due to an initial α-adrenergic vasoconstriction followed by a metabolite-induced vasodilation. These data demonstrate that stimulation of muscle, cutaneous, or mixed nerve afferent C-fibers increases coronary arterial resistance by α-adrenergic vasoconstriction.

UR - http://www.scopus.com/inward/record.url?scp=0024344444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024344444&partnerID=8YFLogxK

M3 - Article

VL - 256

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 6

ER -