Stimulation of cyclic AMP accumulation by 2 chloroadenosine

lack of incorporation of nucleoside into cyclic nucleotides

T. W. Sturgill, B. K. Schrier, A. G. Gilman

Research output: Chapter in Book/Report/Conference proceedingChapter

28 Citations (Scopus)

Abstract

Cultured cells that respond to adenosine and 2 chloroadenosine with stimulation of accumulation of cyclic AMP were incubated with 3H 2 chloroadenosine. Cyclic AMP synthesis was stimulated with isoproterenol or 2 chloroadenosine, and the possible incorporation of 3H into cyclic AMP or 2 chloro cyclic AMP was evaluated. Such incorporation was not found to be significant. There is thus no evidence that 2 chloroadenosine and related nucleosides stimulate cyclic AMP synthesis by increasing the availability of substrate for adenylate cyclase.

Original languageEnglish (US)
Title of host publicationJ.CYCLIC NUCLEOTIDE RES.
Pages21-30
Number of pages10
Volume1
Edition1
StatePublished - 1975

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2-Chloroadenosine
Cyclic Nucleotides
Nucleosides
Cyclic AMP
Isoproterenol
Adenylyl Cyclases
Adenosine
Cultured Cells

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sturgill, T. W., Schrier, B. K., & Gilman, A. G. (1975). Stimulation of cyclic AMP accumulation by 2 chloroadenosine: lack of incorporation of nucleoside into cyclic nucleotides. In J.CYCLIC NUCLEOTIDE RES. (1 ed., Vol. 1, pp. 21-30)

Stimulation of cyclic AMP accumulation by 2 chloroadenosine : lack of incorporation of nucleoside into cyclic nucleotides. / Sturgill, T. W.; Schrier, B. K.; Gilman, A. G.

J.CYCLIC NUCLEOTIDE RES.. Vol. 1 1. ed. 1975. p. 21-30.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sturgill, TW, Schrier, BK & Gilman, AG 1975, Stimulation of cyclic AMP accumulation by 2 chloroadenosine: lack of incorporation of nucleoside into cyclic nucleotides. in J.CYCLIC NUCLEOTIDE RES.. 1 edn, vol. 1, pp. 21-30.
Sturgill TW, Schrier BK, Gilman AG. Stimulation of cyclic AMP accumulation by 2 chloroadenosine: lack of incorporation of nucleoside into cyclic nucleotides. In J.CYCLIC NUCLEOTIDE RES.. 1 ed. Vol. 1. 1975. p. 21-30
Sturgill, T. W. ; Schrier, B. K. ; Gilman, A. G. / Stimulation of cyclic AMP accumulation by 2 chloroadenosine : lack of incorporation of nucleoside into cyclic nucleotides. J.CYCLIC NUCLEOTIDE RES.. Vol. 1 1. ed. 1975. pp. 21-30
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