Stimulation of cyclic AMP accumulation by 2 chloroadenosine: lack of incorporation of nucleoside into cyclic nucleotides

T. W. Sturgill, B. K. Schrier, A. G. Gilman

Research output: Chapter in Book/Report/Conference proceedingChapter

29 Scopus citations

Abstract

Cultured cells that respond to adenosine and 2 chloroadenosine with stimulation of accumulation of cyclic AMP were incubated with 3H 2 chloroadenosine. Cyclic AMP synthesis was stimulated with isoproterenol or 2 chloroadenosine, and the possible incorporation of 3H into cyclic AMP or 2 chloro cyclic AMP was evaluated. Such incorporation was not found to be significant. There is thus no evidence that 2 chloroadenosine and related nucleosides stimulate cyclic AMP synthesis by increasing the availability of substrate for adenylate cyclase.

Original languageEnglish (US)
Title of host publicationJ.CYCLIC NUCLEOTIDE RES.
Pages21-30
Number of pages10
Volume1
Edition1
StatePublished - 1975

ASJC Scopus subject areas

  • Medicine(all)

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    Sturgill, T. W., Schrier, B. K., & Gilman, A. G. (1975). Stimulation of cyclic AMP accumulation by 2 chloroadenosine: lack of incorporation of nucleoside into cyclic nucleotides. In J.CYCLIC NUCLEOTIDE RES. (1 ed., Vol. 1, pp. 21-30)