Stimulation of human sperm capacitation by purified lipid transfer protein

S. E. Ravnik, J. J. Albers, C. H. Muller

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Lipid Transfer Protein I is recognized as a key component involved in high density lipoprotein metabolism. We have been studying lipid transfer in relation to sperm capacitation, a complex series of cell surface events required for the acrosome reaction and fertilization. We have previously shown that Lipid Transfer Protein I is present and active in the female reproductive tract. In the present study, we show that purified Lipid Transfer Protein I directly stimulates human sperm capacitation, but not the acrosome reaction, in the absence of other biological effectors. These results provide strong evidence for a novel role for Lipid Transfer Protein I and reveal, for the first time, a potent activator of capacitation, prior to the acrosome reaction. © 1995 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)78-83
Number of pages6
JournalJournal of Experimental Zoology
Volume272
Issue number1
DOIs
StatePublished - May 1 1995

ASJC Scopus subject areas

  • Animal Science and Zoology

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