Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: Insights gained from a multidisciplinary approach

Christopher B. Newgard, Danhong Lu, Mette Valentin Jensen, Jonathan Schissler, Anne Boucher, Shawn Burgess, A. Dean Sherry

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

There is a growing appreciation for the complexity of the pathways involved in glucose-stimulated insulin secretion (GSIS) from pancreatic islet β-cells. In our laboratory, this has stimulated the development of an interdisciplinary approach to the problem. In this study, we review recent studies combining the tools of recombinant adenovirus for gene delivery, the development of novel cell lines that exhibit either robust or weak GSIS, and nuclear magnetic resonance imaging for metabolic fingerprinting of glucose-stimulated cells. Using these tools, we demonstrate a potentially important role for pyruvate carboxylase -mediated pyruvate cycling pathways in the control of GSIS, and discuss potential coupling factors produced by such pathways.

Original languageEnglish (US)
Pages (from-to)S389-S393
JournalDiabetes
Volume51
Issue numberSUPPL. 3
DOIs
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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