TY - JOUR
T1 - Stochastic model for Soj relocation dynamics in Bacillus subtilis
AU - Doubrovinski, Konstantin
AU - Howard, Martin
PY - 2005/7/12
Y1 - 2005/7/12
N2 - The Bacillus subtilis Spo0J/Soj proteins, implicated in chromosome segregation and transcriptional regulation, show striking dynamics: Soj undergoes irregular relocations from pole to pole or nucleoid to nucleoid. Here, we report on a mathematical model of the Soj dynamics. Our model, which is closely based on the available experimental data, readily generates dynamic Soj relocations. We show that the irregularity of the relocations may be due to the stochastic nature of the underlying Spo0J/Soj interactions and diffusion. We propose explanations for the behavior of several Spo0J Soj mutants, including the "freezing" of the Soj dynamics observed in filamentous cells. Our approach underlines the importance of incorporating stochastic effects when modeling spatiotemporal protein dynamics inside cells.
AB - The Bacillus subtilis Spo0J/Soj proteins, implicated in chromosome segregation and transcriptional regulation, show striking dynamics: Soj undergoes irregular relocations from pole to pole or nucleoid to nucleoid. Here, we report on a mathematical model of the Soj dynamics. Our model, which is closely based on the available experimental data, readily generates dynamic Soj relocations. We show that the irregularity of the relocations may be due to the stochastic nature of the underlying Spo0J/Soj interactions and diffusion. We propose explanations for the behavior of several Spo0J Soj mutants, including the "freezing" of the Soj dynamics observed in filamentous cells. Our approach underlines the importance of incorporating stochastic effects when modeling spatiotemporal protein dynamics inside cells.
KW - Bacteria
KW - Protein oscillations
KW - Spo0J
UR - http://www.scopus.com/inward/record.url?scp=22344445928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22344445928&partnerID=8YFLogxK
U2 - 10.1073/pnas.0500529102
DO - 10.1073/pnas.0500529102
M3 - Article
C2 - 15998739
AN - SCOPUS:22344445928
SN - 0027-8424
VL - 102
SP - 9808
EP - 9813
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 28
ER -