Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin α6β1-ADAM17/tumor necrosis factor-α-converting enzyme (TACE) signaling pathway

Yulian Wang, Zheping Huang, Pritha S. Nayak, Benjamin D. Matthews, David Warburton, Wei Shi, Juan Sanchez-Esteban

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: Mechanical forces are critical for normal fetal lung development. Results: Force applied to α6 1 integrin activates TACE and sheds HB-EGF and TGF-α Conclusion: Mechanical strain enhances binding of α6 1 integrin to TACE to promote fetal type II cell differentiation. Significance: Learning how mechanical forces regulate fetal lung development is critical for the discovery of approaches to accelerate lung maturation.

Original languageEnglish (US)
Pages (from-to)25646-25657
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number35
DOIs
StatePublished - Aug 30 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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