TY - JOUR
T1 - Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin α6β1-ADAM17/tumor necrosis factor-α-converting enzyme (TACE) signaling pathway
AU - Wang, Yulian
AU - Huang, Zheping
AU - Nayak, Pritha S.
AU - Matthews, Benjamin D.
AU - Warburton, David
AU - Shi, Wei
AU - Sanchez-Esteban, Juan
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: Mechanical forces are critical for normal fetal lung development. Results: Force applied to α6 1 integrin activates TACE and sheds HB-EGF and TGF-α Conclusion: Mechanical strain enhances binding of α6 1 integrin to TACE to promote fetal type II cell differentiation. Significance: Learning how mechanical forces regulate fetal lung development is critical for the discovery of approaches to accelerate lung maturation.
AB - Background: Mechanical forces are critical for normal fetal lung development. Results: Force applied to α6 1 integrin activates TACE and sheds HB-EGF and TGF-α Conclusion: Mechanical strain enhances binding of α6 1 integrin to TACE to promote fetal type II cell differentiation. Significance: Learning how mechanical forces regulate fetal lung development is critical for the discovery of approaches to accelerate lung maturation.
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U2 - 10.1074/jbc.M113.473777
DO - 10.1074/jbc.M113.473777
M3 - Article
C2 - 23888051
AN - SCOPUS:84883428714
SN - 0021-9258
VL - 288
SP - 25646
EP - 25657
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 35
ER -