Strand invasion by DNA-peptide conjugates and peptide nucleic acids.

T. Ishihara, D. R. Corey

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Peptide nucleic acids (PNAs) and conjugates between oligonucleotides and cationic peptides possess superior potential for strand invasion at complementary sequences. We discovered that oligonucleotide-peptide conjugates and PNAs fall into three classes based on their hybridization efficiency; i) those complementary to inverted repeats within AT-rich region hybridize with highest efficiency; ii) those complementary to areas adjacent to inverted repeats or near AT-rich regions hybridize with moderate efficiency; and iii) those complementary to other regions do not detectably hybridize. The correlations between oligomer chemistry, DNA target sequence, and hybridization efficiency that we report here have important implications for the recognition of duplex DNA.

Original languageEnglish (US)
Pages (from-to)141-142
Number of pages2
JournalNucleic acids symposium series
Issue number42
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Medicine(all)

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