Strategies to counter weight loss-induced reductions in metabolic rate

Biff F Palmer, Deborah J. Clegg

Research output: Contribution to journalArticle

Abstract

A significant percentage of the population is classified as obese, and there is a growing need to develop novel therapy to reduce body weight. It has long been appreciated that caloric restriction and exercise are the cornerstones of any weight loss method. This review outlines the challenges faced when attempting to achieve weight loss and the metabolic adaptations that ensue upon reductions in body weight which make sustaining weight loss extremely difficult. We discuss the need for novel approaches to weight loss that would increase basal metabolic rate and counter the biological adaptations that provide barriers for maintaining weight reduction. We introduce two metabolic processes, hypobaric hypoxia and cold exposure, which, when activated, cause increased metabolic rate even in the presence of reduced caloric intake. While we do not suggest that these are long-term viable options for methods to achieve weight loss, we are introducing these as pathways that may be targeted to eventually develop novel therapies to achieve sustainable weight loss.

Original languageEnglish (US)
Pages (from-to)258-265
Number of pages8
JournalCurrent Sports Medicine Reports
Volume18
Issue number7
DOIs
StatePublished - Jul 1 2019

Fingerprint

Weight Loss
Biological Adaptation
Body Weight
Basal Metabolism
Caloric Restriction
Energy Intake
Therapeutics
Population

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health

Cite this

Strategies to counter weight loss-induced reductions in metabolic rate. / Palmer, Biff F; Clegg, Deborah J.

In: Current Sports Medicine Reports, Vol. 18, No. 7, 01.07.2019, p. 258-265.

Research output: Contribution to journalArticle

@article{273f6284e1d640fa831154c067c07449,
title = "Strategies to counter weight loss-induced reductions in metabolic rate",
abstract = "A significant percentage of the population is classified as obese, and there is a growing need to develop novel therapy to reduce body weight. It has long been appreciated that caloric restriction and exercise are the cornerstones of any weight loss method. This review outlines the challenges faced when attempting to achieve weight loss and the metabolic adaptations that ensue upon reductions in body weight which make sustaining weight loss extremely difficult. We discuss the need for novel approaches to weight loss that would increase basal metabolic rate and counter the biological adaptations that provide barriers for maintaining weight reduction. We introduce two metabolic processes, hypobaric hypoxia and cold exposure, which, when activated, cause increased metabolic rate even in the presence of reduced caloric intake. While we do not suggest that these are long-term viable options for methods to achieve weight loss, we are introducing these as pathways that may be targeted to eventually develop novel therapies to achieve sustainable weight loss.",
author = "Palmer, {Biff F} and Clegg, {Deborah J.}",
year = "2019",
month = "7",
day = "1",
doi = "10.1249/JSR.0000000000000610",
language = "English (US)",
volume = "18",
pages = "258--265",
journal = "Current Sports Medicine Reports",
issn = "1537-890X",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Strategies to counter weight loss-induced reductions in metabolic rate

AU - Palmer, Biff F

AU - Clegg, Deborah J.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - A significant percentage of the population is classified as obese, and there is a growing need to develop novel therapy to reduce body weight. It has long been appreciated that caloric restriction and exercise are the cornerstones of any weight loss method. This review outlines the challenges faced when attempting to achieve weight loss and the metabolic adaptations that ensue upon reductions in body weight which make sustaining weight loss extremely difficult. We discuss the need for novel approaches to weight loss that would increase basal metabolic rate and counter the biological adaptations that provide barriers for maintaining weight reduction. We introduce two metabolic processes, hypobaric hypoxia and cold exposure, which, when activated, cause increased metabolic rate even in the presence of reduced caloric intake. While we do not suggest that these are long-term viable options for methods to achieve weight loss, we are introducing these as pathways that may be targeted to eventually develop novel therapies to achieve sustainable weight loss.

AB - A significant percentage of the population is classified as obese, and there is a growing need to develop novel therapy to reduce body weight. It has long been appreciated that caloric restriction and exercise are the cornerstones of any weight loss method. This review outlines the challenges faced when attempting to achieve weight loss and the metabolic adaptations that ensue upon reductions in body weight which make sustaining weight loss extremely difficult. We discuss the need for novel approaches to weight loss that would increase basal metabolic rate and counter the biological adaptations that provide barriers for maintaining weight reduction. We introduce two metabolic processes, hypobaric hypoxia and cold exposure, which, when activated, cause increased metabolic rate even in the presence of reduced caloric intake. While we do not suggest that these are long-term viable options for methods to achieve weight loss, we are introducing these as pathways that may be targeted to eventually develop novel therapies to achieve sustainable weight loss.

UR - http://www.scopus.com/inward/record.url?scp=85068622366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85068622366&partnerID=8YFLogxK

U2 - 10.1249/JSR.0000000000000610

DO - 10.1249/JSR.0000000000000610

M3 - Article

C2 - 31283626

AN - SCOPUS:85068622366

VL - 18

SP - 258

EP - 265

JO - Current Sports Medicine Reports

JF - Current Sports Medicine Reports

SN - 1537-890X

IS - 7

ER -