Strategies to reduce risk factors in hypertensive patients who smoke

Norman M Kaplan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hypertensive patients who smoke have a high risk of developing premature cardiovascular disease. In addition to encouraging these patients to stop smoking, effective nondrug therapies include weight reduction, salt restriction, and alcohol limitation. For patients whose hypertension is severe or who have other health problems, antihypertensive drug therapy is also used. In the past, diuretics and beta-blockers have proved popular. However, these drugs have produced biochemical disturbances, such as diuretic-induced hypokalemia and both diuretic- and beta-blocker-induced alterations in blood lipids. The hazard of such drug-induced alterations may be greater in hypertensive patients, who may already suffer from hypercholesterolemia. Other drugs are available that can treat hypertension with no or beneficial influence on blood lipids. For smokers, the selective α1-receptor inhibitors may be more attractive, since they also act to counteract the vasoconstriction produced by nicotine. In the future, inhibitors of hydroxymethylglutaryl coenzyme A reductase may offer potential for effective control of blood lipids in hypertensive patients who smoke.

Original languageEnglish (US)
Pages (from-to)288-294
Number of pages7
JournalAmerican Heart Journal
Volume115
Issue number1 PART 2
DOIs
StatePublished - 1988

Fingerprint

Smoke
Diuretics
Lipids
Pharmaceutical Preparations
Hypertension
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hypokalemia
Hypercholesterolemia
Vasoconstriction
Nicotine
Antihypertensive Agents
Weight Loss
Oxidoreductases
Cardiovascular Diseases
Salts
Smoking
Alcohols
Drug Therapy
Health
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Strategies to reduce risk factors in hypertensive patients who smoke. / Kaplan, Norman M.

In: American Heart Journal, Vol. 115, No. 1 PART 2, 1988, p. 288-294.

Research output: Contribution to journalArticle

Kaplan, Norman M. / Strategies to reduce risk factors in hypertensive patients who smoke. In: American Heart Journal. 1988 ; Vol. 115, No. 1 PART 2. pp. 288-294.
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