Streptozotocin in advanced small cell bronchogenic carcinoma: An ineffective nonmyelosuppressive agent

P. A. Bunn; D. C. Ihde; M. H. Cohen; S. E. Shackney; J. D. Minna

Streptozotocin in advanced small cell bronchogenic carcinoma: An ineffective nonmyelosuppressive agent

P. A. Bunn, D. C. Ihde, M. H. Cohen, S. E. Shackney, J. D. Minna

Research output: Contribution to journal › Article › peer-review

Abstract

Thirteen patients with advanced small cell bronchogenic carcinoma (SCBC) received at least three weekly cycles of iv streptozotocin (STZ). There were no objective responses. Four patients progressed by the third week of therapy and an additional eight by the fourth week. Toxicity was acceptable especially in view of the extensive prior therapy. STZ is unlikely to be of benefit in combination chemotherapy regimens for SCBC.

Original language	English (US)
Pages (from-to)	479-481
Number of pages	3
Journal	Cancer Treatment Reports
Volume	62
Issue number	3
State	Published - Dec 1 1978

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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abstract = "Thirteen patients with advanced small cell bronchogenic carcinoma (SCBC) received at least three weekly cycles of iv streptozotocin (STZ). There were no objective responses. Four patients progressed by the third week of therapy and an additional eight by the fourth week. Toxicity was acceptable especially in view of the extensive prior therapy. STZ is unlikely to be of benefit in combination chemotherapy regimens for SCBC.",

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AU - Bunn, P. A.

AU - Ihde, D. C.

AU - Cohen, M. H.

AU - Shackney, S. E.

AU - Minna, J. D.

PY - 1978/12/1

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N2 - Thirteen patients with advanced small cell bronchogenic carcinoma (SCBC) received at least three weekly cycles of iv streptozotocin (STZ). There were no objective responses. Four patients progressed by the third week of therapy and an additional eight by the fourth week. Toxicity was acceptable especially in view of the extensive prior therapy. STZ is unlikely to be of benefit in combination chemotherapy regimens for SCBC.

AB - Thirteen patients with advanced small cell bronchogenic carcinoma (SCBC) received at least three weekly cycles of iv streptozotocin (STZ). There were no objective responses. Four patients progressed by the third week of therapy and an additional eight by the fourth week. Toxicity was acceptable especially in view of the extensive prior therapy. STZ is unlikely to be of benefit in combination chemotherapy regimens for SCBC.

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Streptozotocin in advanced small cell bronchogenic carcinoma: An ineffective nonmyelosuppressive agent

Abstract

ASJC Scopus subject areas

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