TY - JOUR
T1 - Stress-induced analgesia
AU - Butler, Ryan K.
AU - Finn, David P.
N1 - Funding Information:
This work was supported by a grant from Science Foundation Ireland.
PY - 2009/7
Y1 - 2009/7
N2 - For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, γ-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.
AB - For over 30 years, scientists have been investigating the phenomenon of pain suppression upon exposure to unconditioned or conditioned stressful stimuli, commonly known as stress-induced analgesia. These studies have revealed that individual sensitivity to stress-induced analgesia can vary greatly and that this sensitivity is coupled to many different phenotypes including the degree of opioid sensitivity and startle response. Furthermore, stress-induced analgesia is influenced by age, gender, and prior experience to stressful, painful, or other environmental stimuli. Stress-induced analgesia is mediated by activation of the descending inhibitory pain pathway. Pharmacological and neurochemical studies have demonstrated involvement of a large number of neurotransmitters and neuropeptides. In particular, there are key roles for the endogenous opioid, monoamine, cannabinoid, γ-aminobutyric acid and glutamate systems. The study of stress-induced analgesia has enhanced our understanding of the fundamental physiology of pain and stress and can be a useful approach for uncovering new therapeutic targets for the treatment of pain and stress-related disorders.
KW - Fear
KW - Human
KW - Pain
KW - Rodent
KW - Stress-induced analgesia
UR - http://www.scopus.com/inward/record.url?scp=67349120237&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349120237&partnerID=8YFLogxK
U2 - 10.1016/j.pneurobio.2009.04.003
DO - 10.1016/j.pneurobio.2009.04.003
M3 - Review article
C2 - 19393288
AN - SCOPUS:67349120237
SN - 0301-0082
VL - 88
SP - 184
EP - 202
JO - Progress in Neurobiology
JF - Progress in Neurobiology
IS - 3
ER -